The Molecular and Cellular Identity of Peripheral Osmoreceptors

• Published in: Neuron (Cambridge, Mass.) Vol. 69; no. 2; pp. 332 - 344
• Main Authors: Lechner, Stefan G., Markworth, Sören, Poole, Kate, Smith, Ewan St. John, Lapatsina, Liudmilla, Frahm, Silke, May, Marcus, Pischke, Sven, Suzuki, Makoto, Ibañez-Tallon, Inés, Luft, Friedrich C., Jordan, Jens, Lewin, Gary R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.01.2011; Elsevier Limited
• Subjects: Animals; Calcium - metabolism; Cells, Cultured; Chemoreceptor Cells - cytology; Chemoreceptor Cells - physiology; Drinking; Extracellular Fluid - chemistry; Ganglia, Spinal - cytology; Gene expression; Homeostasis; Humans; Kinases; Liver - blood supply; Liver - chemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Nervous system; Neurons; Neurons, Afferent - cytology; Neurons, Afferent - physiology; Osmolar Concentration; Patch-Clamp Techniques; Phorbols - metabolism; Proteins; Rodents; Thermogenesis; TRPV Cation Channels - antagonists & inhibitors; TRPV Cation Channels - genetics; TRPV Cation Channels - metabolism; Veins & arteries; Water-Electrolyte Balance - physiology; Jordan (country)

In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is trigge...