Sex- and cell-dependent contribution of peripheral high mobility group box 1 and TLR4 in arthritis-induced pain

• Published in: Pain (Amsterdam) Vol. 162; no. 2; pp. 459 - 470
• Main Authors: Rudjito, Resti, Agalave, Nilesh M, Farinotti, Alex Bersellini, Lundbäck, Peter, Szabo-Pardi, Thomas A, Price, Theodore J, Harris, Helena Erlandsson, Burton, Michael D, Svensson, Camilla I
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.02.2021
• Subjects: Animals; Female; HMGB1 Protein - genetics; Macrophages; Male; Medicin och hälsovetenskap; Mice; Nociception; Pain - etiology; Research Paper; Toll-Like Receptor 4 - genetics

Spinal high mobility group box 1 protein (HMGB1) plays crucial roles in arthritis-induced pain; however, the involvement of peripheral HMGB1 has not been examined previously. In this study, we addressed the role of peripheral HMGB1 and explored if sex contributes differentially to nociception in art...