Fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids
Dietary polyunsaturated fatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the fatty acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatty acid composition may influence bone cell signalling and, potentially, bone mineralization....
Saved in:
| Published in | Applied physiology, nutrition, and metabolism Vol. 35; no. 4; pp. 447 - 455 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ottawa
Presses scientifiques du CNRC
01.08.2010
NRC Research Press Canadian Science Publishing NRC Research Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1715-5312 1715-5320 |
| DOI | 10.1139/H10-029 |
Cover
| Abstract | Dietary polyunsaturated fatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the fatty acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatty acid composition may influence bone cell signalling and, potentially, bone mineralization. The objective of this study was to use the fat-1 mouse, a transgenic model that synthesizes n-3 from n-6 PUFA, to determine if the fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids, and if so, whether the fatty acid levels would correlate with bone mineral density (BMD) at both skeletal sites. Male and female wild-type and fat-1 mice were fed an AIN93-G diet, containing 10% safflower oil, from weaning to 12 weeks of age. The fatty acid composition of femoral and vertebral phospholipids was measured by gas liquid chromatography. At 12 weeks of age, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine fractions in the vertebrae of fat-1 mice had a significantly lower n-6/n-3 ratio than wild-type mice (p < 0.05). In fat-1 femurs, these fractions, along with phosphatidylinositol, had a lower n-6/n-3 ratio than wild-type mice (p < 0.001). Docosahexaenoic acid (DHA) was positively correlated with BMD in all fractions in the vertebrae, and in phosphatidylinositol and phosphatidylserine in the femur (p < 0.05). Overall, the fat-1 gene resulted in changes in the fatty acid composition of both femoral and vertebral phospholipids. Significant correlations between DHA and BMD may indicate a positive effect on bone mineralization. |
|---|---|
| AbstractList | Dietary polyunsaturated fatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the fatty acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatty acid composition may influence bone cell signalling and, potentially, bone mineralization. The objective of this study was to use the fat-1 mouse, a transgenic model that synthesizes n-3 from n-6 PUFA, to determine if the fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids, and if so, whether the fatty acid levels would correlate with bone mineral density (BMD) at both skeletal sites. Male and female wild-type and fat-1 mice were fed an AIN93-G diet, containing 10% safflower oil, from weaning to 12 weeks of age. The fatty acid composition of femoral and vertebral phospholipids was measured by gas liquid chromatography. At 12 weeks of age, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine fractions in the vertebrae of fat-1 mice had a significantly lower n-6/n-3 ratio than wild-type mice (p<0.05). In fat-1 femurs, these fractions, along with phosphatidylinositol, had a lower n-6/n-3 ratio than wild-type mice (p<0.001). Docosahexaenoic acid (DHA) was positively correlated with BMD in all fractions in the vertebrae, and in phosphatidylinositol and phosphatidylserine in the femur (p<0.05). Overall, the fat-1 gene resulted in changes in the fatty acid composition of both femoral and vertebral phospholipids. Significant correlations between DHA and BMD may indicate a positive effect on bone mineralization. Dietary polyunsaturated tatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the Tally acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatly acid composition may influence bone cell signalling and, potentially, bone mineralization. The objective of this study was to use the fat-1 mouse, a transgenic model thai synthesizes n-3 from n-6 PUFA, to determine if the fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids, and if so, whether the fatty acid levels would correlate with bone mineral density (BMD) at both skeletal sites. Male and female wild-type and fat-1 mice were fed an A1N93-G diet, containing 10% safflower oil, from weaning to 12 weeks of age. The fatty acid composition of femoral and vertebral phospholipids was measured by gas liquid chromatography. At 12 weeks of age, phosphatidylcholine, phosphatidylethanolamine, and phosphatidyl serine fractions in the vertebrae of fat-1 mice had a significantly lower n-6/n-3 ratio than wild-type mice (p < 0.05). In fat-1 femurs, these fractions, along with phosphatidyl inositol, had a lower n-6/n-3 ratio than wild-type mice (p < 0.001). Docosahexaenoic acid (DHA) was positively correlated with BMD in all fractions in the vertebrae, and in phosphatidylinositol and phosphatidyl serine in the femur (p < 0.05). Overall, the fat-1 gene resulted in changes in the fatty acid composition of both femoral and vertebral phospholipids. Significant correlations between DHA and BMD may indicate a positive effect on bone mineralization. Key words: fatty acids, phospholipids, bone mineral density, bone development, mice. L'integration des acides gras polyinsatures (PUFA) alimentaires dans le tissu osseux pent affecter le metabolisme par alteration de la composition en acides gras des phospholipides de la membrane. La modification de la composition en acides gras des phospholipides membranaires pourrait influencer la signalisation dans les cellules osseuses et, de ce fait, la mineralisation des os. Celte etude se propose de verifier chez la souris fat-1, une souris transgenique pouvant syniheliser des PUFA (n-3) a partir de PUFA (17-6) si le gene de la souris fat-1 module la composition en acides gras des phospholipides de la membrane osseuse dn femur et des vertebres et, le cas echeant, de determiner la correlation entre la concentration d'acides gras et la densite minerale osseuse (BMD) dans les deux os. On soumet des souris males et femelles de type sauvage et de type fat-1 a une diete AIN93-G contenant 10 % d'huile de carthame depuis la periode de sevrage jusqu'a l'age de 12 semaines. On mesure la composition en acides gras des phospholipides femoraux et vertebraux par chromatographie en phase gazeuse. A la douzieme semaine, la phosphatidylcholine, la phosphatidylethanolamine et la phosphatidylserine des vertebres des souris fat-1 presentenl un ratio n-6/n-3 significativement inferieur a celui des souris de lype sauvage (p < 0,05). Dans les femurs des souris de type fat-1, on observe le meme phenomene en plus de noier un plus faible ratio n-6/n-3 dans le phosphatidylinositol (p < 0,001) que chez les souris de type sauvage. La concentration d'acide docosahexaenoique (DHA) est positivement associee a la BMD des vertebres et il en est de meme des concentrations de phosphatidylinositol et de phosphatidylserine en ce qui concerne la BMD du femur (p < 0.05). Globalement, le gene fat-1 suscite des modifications de la composition en acides gras des phospholipides membranaires du femur el des vertebres. Les correlations significatives entre la concentration de DHA et la BMD indiquent des effets potentiels positifs sur la mineralisation. Mots-cles : acides gras, phospholipides, densite minerale osseuse, developpement osseux, souris. [Traduit par la Redaction] Dietary polyunsaturated fatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the fatty acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatty acid composition may influence bone cell signalling and, potentially, bone mineralization. The objective of this study was to use the fat-1 mouse, a transgenic model that synthesizes n-3 from n-6 PUFA, to determine if the fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids, and if so, whether the fatty acid levels would correlate with bone mineral density (BMD) at both skeletal sites. Male and female wild-type and fat-1 mice were fed an AIN93-G diet, containing 10% safflower oil, from weaning to 12 weeks of age. The fatty acid composition of femoral and vertebral phospholipids was measured by gas liquid chromatography. At 12 weeks of age, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine fractions in the vertebrae of fat-1 mice had a significantly lower n-6/n-3 ratio than wild-type mice (p<0.05). In fat-1 femurs, these fractions, along with phosphatidylinositol, had a lower n-6/n-3 ratio than wild-type mice (p<0.001). Docosahexaenoic acid (DHA) was positively correlated with BMD in all fractions in the vertebrae, and in phosphatidylinositol and phosphatidylserine in the femur (p<0.05). Overall, the fat-1 gene resulted in changes in the fatty acid composition of both femoral and vertebral phospholipids. Significant correlations between DHA and BMD may indicate a positive effect on bone mineralization.Dietary polyunsaturated fatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the fatty acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatty acid composition may influence bone cell signalling and, potentially, bone mineralization. The objective of this study was to use the fat-1 mouse, a transgenic model that synthesizes n-3 from n-6 PUFA, to determine if the fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids, and if so, whether the fatty acid levels would correlate with bone mineral density (BMD) at both skeletal sites. Male and female wild-type and fat-1 mice were fed an AIN93-G diet, containing 10% safflower oil, from weaning to 12 weeks of age. The fatty acid composition of femoral and vertebral phospholipids was measured by gas liquid chromatography. At 12 weeks of age, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine fractions in the vertebrae of fat-1 mice had a significantly lower n-6/n-3 ratio than wild-type mice (p<0.05). In fat-1 femurs, these fractions, along with phosphatidylinositol, had a lower n-6/n-3 ratio than wild-type mice (p<0.001). Docosahexaenoic acid (DHA) was positively correlated with BMD in all fractions in the vertebrae, and in phosphatidylinositol and phosphatidylserine in the femur (p<0.05). Overall, the fat-1 gene resulted in changes in the fatty acid composition of both femoral and vertebral phospholipids. Significant correlations between DHA and BMD may indicate a positive effect on bone mineralization. Dietary polyunsaturated fatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the fatty acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatty acid composition may influence bone cell signalling and, potentially, bone mineralization. The objective of this study was to use the fat-1 mouse, a transgenic model that synthesizes n-3 from n-6 PUFA, to determine if the fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids, and if so, whether the fatty acid levels would correlate with bone mineral density (BMD) at both skeletal sites. Male and female wild-type and fat-1 mice were fed an AIN93-G diet, containing 10% safflower oil, from weaning to 12 weeks of age. The fatty acid composition of femoral and vertebral phospholipids was measured by gas liquid chromatography. At 12 weeks of age, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine fractions in the vertebrae of fat-1 mice had a significantly lower n-6/n-3 ratio than wild-type mice (p < 0.05). In fat-1 femurs, these fractions, along with phosphatidylinositol, had a lower n-6/n-3 ratio than wild-type mice (p < 0.001). Docosahexaenoic acid (DHA) was positively correlated with BMD in all fractions in the vertebrae, and in phosphatidylinositol and phosphatidylserine in the femur (p < 0.05). Overall, the fat-1 gene resulted in changes in the fatty acid composition of both femoral and vertebral phospholipids. Significant correlations between DHA and BMD may indicate a positive effect on bone mineralization. Dietary polyunsaturated tatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the Tally acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatly acid composition may influence bone cell signalling and, potentially, bone mineralization. The objective of this study was to use the fat-1 mouse, a transgenic model thai synthesizes n-3 from n-6 PUFA, to determine if the fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids, and if so, whether the fatty acid levels would correlate with bone mineral density (BMD) at both skeletal sites. Male and female wild-type and fat-1 mice were fed an A1N93-G diet, containing 10% safflower oil, from weaning to 12 weeks of age. The fatty acid composition of femoral and vertebral phospholipids was measured by gas liquid chromatography. At 12 weeks of age, phosphatidylcholine, phosphatidylethanolamine, and phosphatidyl serine fractions in the vertebrae of fat-1 mice had a significantly lower n-6/n-3 ratio than wild-type mice (p < 0.05). In fat-1 femurs, these fractions, along with phosphatidyl inositol, had a lower n-6/n-3 ratio than wild-type mice (p < 0.001). Docosahexaenoic acid (DHA) was positively correlated with BMD in all fractions in the vertebrae, and in phosphatidylinositol and phosphatidyl serine in the femur (p < 0.05). Overall, the fat-1 gene resulted in changes in the fatty acid composition of both femoral and vertebral phospholipids. Significant correlations between DHA and BMD may indicate a positive effect on bone mineralization. Dietary polyunsaturated fatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the fatty acid composition of membrane phospholipids. Alteration of the membrane phospholipid fatty acid composition may influence bone cell signalling and, potentially, bone mineralization. The objective of this study was to use the fat-1 mouse, a transgenic model that synthesizes n-3 from n-6 PUFA, to determine if the fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids, and if so, whether the fatty acid levels would correlate with bone mineral density (BMD) at both skeletal sites. Male and female wild-type and fat-1 mice were fed an AIN93-G diet, containing 10% safflower oil, from weaning to 12 weeks of age. The fatty acid composition of femoral and vertebral phospholipids was measured by gas liquid chromatography. At 12 weeks of age, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine fractions in the vertebrae of fat-1 mice had a significantly lower n-6/n-3 ratio than wild-type mice (p < 0.05). In fat-1 femurs, these fractions, along with phosphatidylinositol, had a lower n-6/n-3 ratio than wild-type mice (p < 0.001). Docosahexaenoic acid (DHA) was positively correlated with BMD in all fractions in the vertebrae, and in phosphatidylinositol and phosphatidylserine in the femur (p < 0.05). Overall, the fat-1 gene resulted in changes in the fatty acid composition of both femoral and vertebral phospholipids. Significant correlations between DHA and BMD may indicate a positive effect on bone mineralization.Original Abstract: L'integration des acides gras polyinsatures (PUFA) alimentaires dans le tissu osseux peut affecter le metabolisme par alteration de la composition en acides gras des phospholipides de la membrane. La modification de la composition en acides gras des phospholipides membranaires pourrait influencer la signalisation dans les cellules osseuses et, de ce fait, la mineralisation des os. Cette etude se propose de verifier chez la souris fat-1, une souris transgenique pouvant synthetiser des PUFA (n-3) a partir de PUFA (n-6) si le gene de la souris fat-1 module la composition en acides gras des phospholipides de la membrane osseuse du femur et des vertebres et, le cas echeant, de determiner la correlation entre la concentration d'acides gras et la densite minerale osseuse (BMD) dans les deux os. On soumet des souris males et femelles de type sauvage et de type fat-1 a une diete AIN93-G contenant 10 % d'huile de carthame depuis la periode de sevrage jusqu'a l'age de 12 semaines. On mesure la composition en acides gras des phospholipides femoraux et vertebraux par chromatographie en phase gazeuse. A la douzieme semaine, la phosphatidylcholine, la phosphatidylethanolamine et la phosphatidylserine des vertebres des souris fat-1 presentent un ratio n-6/n-3 significativement inferieur a celui des souris de type sauvage (p < 0,05). Dans les femurs des souris de type fat-1, on observe le meme phenomene en plus de noter un plus faible ratio n-6/n-3 dans le phosphatidylinositol (p < 0,001) que chez les souris de type sauvage. La concentration d'acide docosahexaenoieque (DHA) est positivement associee a la BMD des vertebres et il en est de meme des concentrations de phosphatidylinositol et de phosphatidylserine en ce qui concerne la BMD du femur (p < 0,05). Globalement, le gene fat-1 suscite des modifications de la composition en acides gras des phospholipides membranaires du femur et des vertebres. Les correlations significatives entre la concentration de DHA et la BMD indiquent des effets potentiels positifs sur la mineralisation. |
| Abstract_FL | L'intégration des acides gras polyinsaturés (PUFA) alimentaires dans le tissu osseux peut affecter le métabolisme par altération de la composition en acides gras des phospholipides de la membrane. La modification de la composition en acides gras des phospholipides membranaires pourrait influencer la signalisation dans les cellules osseuses et, de ce fait, la minéralisation des os. Cette étude se propose de vérifier chez la souris fat-1, une souris transgénique pouvant synthétiser des PUFA (n-3) à partir de PUFA (n-6) si le gène de la souris fat-1 module la composition en acides gras des phospholipides de la membrane osseuse du fémur et des vertèbres et, le cas échéant, de déterminer la corrélation entre la concentration d'acides gras et la densité minérale osseuse (BMD) dans les deux os. On soumet des souris mâles et femelles de type sauvage et de type fat-1 à une diète AIN93-G contenant 10 % d'huile de carthame depuis la période de sevrage jusqu'à l'âge de 12 semaines. On mesure la composition en acides gras des phospholipides fémoraux et vertébraux par chromatographie en phase gazeuse. A la douzième semaine, la phosphatidylcholine, la phosphatidyléthanolamine et la phosphatidylsérine des vertèbres des souris fat-1 présentent un ratio n-6/n-3 significativement inférieur à celui des souris de type sauvage (p < 0,05). Dans les fémurs des souris de type fat-1, on observe le même phénomène en plus de noter un plus faible ratio n-6/n-3 dans le phosphatidylinositol (p < 0,001) que chez les souris de type sauvage. La concentration d'acide docosahexaénoïque (DHA) est positivement associée à la BMD des vertèbres et il en est de même des concentrations de phosphatidylinositol et de phosphatidylsérine en ce qui concerne la BMD du fémur (p < 0,05). Globalement, le gène fat-1 suscite des modifications de la composition en acides gras des phospholipides membranaires du fémur et des vertèbres. Les corrélations significatives entre la concentration de DHA et la BMD indiquent des effets potentiels positifs sur la minéralisation. |
| Audience | Academic |
| Author | Ma, David W.L Kang, Jing X Lau, Beatrice Y.Y Ward, Wendy E |
| Author_xml | – sequence: 1 givenname: Beatrice Y.Y surname: Lau fullname: Lau, Beatrice Y.Y organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada – sequence: 2 givenname: Wendy E surname: Ward fullname: Ward, Wendy E organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada – sequence: 3 givenname: Jing X surname: Kang fullname: Kang, Jing X organization: Department of Medicine, Harvard Medical School, Boston, MA, USA – sequence: 4 givenname: David W.L surname: Ma fullname: Ma, David W.L email: davidma@uoguelph.ca organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23253928$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20725110$$D View this record in MEDLINE/PubMed |
| BookMark | eNqF0l1r1jAUAOAgEzfn8B9IUJwgdOajadLLMZwTBt6otyFNkzWSNjVJhf17U_tuc37SlKblyenJyXkM9qYwGQCeYnSCMW3fXGBUIdI-AAeYY1YxStDe7RyTfXCUkusQQoIIwckjsE8QJwxjdAA-n6tcYXhlJgPH0C9eZZNgHgy0KudrqLTroQ7jHJLLLkwwWGjNGKLyUE09_GZiNt36Ng8hldu72fXpCXholU_maPc8BJ_O3348u6guP7x7f3Z6WWlGaa46xKhFiJCGMEG56SjmwnKqCcKaNURoJWrOMeINZYQozDRpe04Z7tpOUUoPwast7hzD18WkLEeXtPFeTSYsSXJWC1EKQv4va9G2JRNR5PNf5JewxKlsoyDWNqiMgl5s6Ep5I91kQ45KryHlKakpx3XdNEWd_EGVqzej0-UUrSvf7y04_mnBYJTPQwp-WUuf7sNnuySXbjS9nKMbVbyWNydbwMsdUEkrb6OatEt3jhJG2x-7rTanY0gpGiu1y2r9X0nVeYmRXJtMliaTpcnu6njrb0L-Ll9vcoo6mmRU1MM_8PHf8bAhOfeWfgdrPeSw |
| CitedBy_id | crossref_primary_10_1093_nutrit_nuv035 crossref_primary_10_1016_j_jnutbio_2014_01_012 crossref_primary_10_1186_1476_511X_11_60 crossref_primary_10_1139_apnm_2013_0157 crossref_primary_10_3390_ijms12042408 crossref_primary_10_3402_ijch_v72i0_20988 crossref_primary_10_1016_j_plipres_2015_06_002 crossref_primary_10_3928_01477447_20120822_42 crossref_primary_10_3390_molecules181114203 crossref_primary_10_3390_ijms25053024 crossref_primary_10_1016_j_jnutbio_2022_109245 crossref_primary_10_1016_j_plefa_2013_08_002 crossref_primary_10_1093_jbmrpl_ziad011 crossref_primary_10_1155_2012_354151 |
| Cites_doi | 10.1038/427504a 10.1159/isbn.978-3-318-04339-6 10.1016/j.appet.2009.03.007 10.1016/S0163-7827(00)00016-3 10.1016/j.plefa.2006.05.013 10.1016/j.jnutbio.2005.05.012 10.1007/BF02012794 10.1007/s11745-003-1115-8 10.1016/S0034-5288(18)32024-1 10.1016/S0021-9258(18)64849-5 10.1093/ajcn/70.3.560s 10.1038/nrm2330 10.1017/S0029665100000021 10.1093/ajcn/81.4.934 10.1007/s11745-001-0798-1 10.1016/S0163-7827(97)00007-6 10.1016/j.appet.2008.01.005 10.1016/j.jnutbio.2005.01.019 10.1074/jbc.M707653200 10.1042/bj2120573 10.1111/j.1582-4934.2008.00649.x 10.1301/nr.2006.may.S24-S33 10.1007/s11745-999-0424-2 10.1079/BJN20051664 10.1093/jn/134.2.388 10.1007/BF02534120 10.1093/jn/130.9.2274 10.3181/0808-RM-247 10.1111/j.1532-5415.2008.01870.x 10.1016/0305-0491(83)90079-2 10.1042/bj2110507 10.1016/j.jnutbio.2008.05.004 10.1038/nm1591 10.1007/s00223-007-9010-8 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS COPYRIGHT 2010 NRC Research Press Copyright Human Kinetics Aug 2010 |
| Copyright_xml | – notice: 2015 INIST-CNRS – notice: COPYRIGHT 2010 NRC Research Press – notice: Copyright Human Kinetics Aug 2010 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7TS 7X8 7QP |
| DOI | 10.1139/H10-029 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Physical Education Index MEDLINE - Academic Calcium & Calcified Tissue Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Physical Education Index MEDLINE - Academic Calcium & Calcified Tissue Abstracts |
| DatabaseTitleList | MEDLINE MEDLINE - Academic CrossRef Calcium & Calcified Tissue Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Diet & Clinical Nutrition Recreation & Sports |
| EISSN | 1715-5320 |
| EndPage | 455 |
| ExternalDocumentID | 2115415591 A243714466 20725110 23253928 10_1139_H10_029 h10-029 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Feature |
| GroupedDBID | 0R 186 23M 2QV 4.4 53G 5GY 5RP AAIKC AAWTL ABDBF ABFLS ABFSI ABPTK ACGFS ADHUB AENEX ALMA_UNASSIGNED_HOLDINGS C1A CAG COF CS3 D8U DL DXH E.L EAD EAP EAS EBD EBS EJD EMK ESX F5P HZ H~9 IAO IEA IFM IHR IHW INH INR ITC NRXXU O9- OHT PQEST PQQKQ PV9 RIG RRP RZL TUS UKR UPT X XFK -~X 00T 0R~ 36B AAFWJ AAHBH AAMNW AAYXX ABJNI ACGFO ACUHS CITATION DATHI HZ~ IPNFZ IPT VQG ZY4 IQODW CGR CUY CVF ECM EIF NPM 7TS 7X8 7QP |
| ID | FETCH-LOGICAL-c533t-b053f0022625837eb3178f73c201c5628ca847710763522a15c29d7351b9ba333 |
| ISSN | 1715-5312 |
| IngestDate | Fri Jul 11 13:08:10 EDT 2025 Fri Jul 11 10:31:48 EDT 2025 Sun Jun 29 16:30:32 EDT 2025 Wed Mar 19 00:27:09 EDT 2025 Sat Mar 08 18:25:50 EST 2025 Thu May 22 21:23:56 EDT 2025 Mon Jul 21 05:52:51 EDT 2025 Mon Jul 21 09:13:10 EDT 2025 Wed Aug 20 07:43:21 EDT 2025 Thu Apr 24 22:52:38 EDT 2025 Wed Nov 11 00:34:05 EST 2020 Thu May 23 14:04:36 EDT 2019 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Human Vertebrata Mammalia Gene Mouse Rodentia Development Fat Phospholipid Lipids Bone mineral density Fatty acids |
| Language | English |
| License | http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c533t-b053f0022625837eb3178f73c201c5628ca847710763522a15c29d7351b9ba333 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 |
| PMID | 20725110 |
| PQID | 745960960 |
| PQPubID | 28783 |
| PageCount | 9 |
| ParticipantIDs | pascalfrancis_primary_23253928 proquest_miscellaneous_748990228 gale_infotracmisc_A243714466 gale_healthsolutions_A243714466 proquest_miscellaneous_754885322 gale_infotracacademiconefile_A243714466 pubmed_primary_20725110 nrcresearch_primary_10_1139_H10_029 proquest_journals_745960960 crossref_citationtrail_10_1139_H10_029 crossref_primary_10_1139_H10_029 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-08-01 |
| PublicationDateYYYYMMDD | 2010-08-01 |
| PublicationDate_xml | – month: 08 year: 2010 text: 2010-08-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Ottawa |
| PublicationPlace_xml | – name: Ottawa – name: Canada |
| PublicationTitle | Applied physiology, nutrition, and metabolism |
| PublicationTitleAlternate | Physiologie appliquée, nutrition et métabolisme |
| PublicationYear | 2010 |
| Publisher | Presses scientifiques du CNRC NRC Research Press Canadian Science Publishing NRC Research Press |
| Publisher_xml | – name: Presses scientifiques du CNRC – name: NRC Research Press – name: Canadian Science Publishing NRC Research Press |
| References | Rahman M.M. (rg19/ref19) 2009; 13 rg23/ref23 rg21/ref21 Boskey A.L. (rg1/ref1) 1976; 19 Folch J. (rg9/ref9) 1957; 226 Clandinin M.T. (rg5/ref5) 1983; 35 rg12/ref12 rg32/ref32 Neelands P.J. (rg18/ref18) 1983; 212 Foot M. (rg10/ref10) 1983; 211 rg16/ref16 rg33/ref33 rg27/ref27 rg4/ref4 rg30/ref30 rg7/ref7 Simopoulos A.P. (rg24/ref24) 1999; 70 rg22/ref22 rg13/ref13 rg29/ref29 rg6/ref6 rg11/ref11 rg3/ref3 rg15/ref15 rg36/ref36 rg26/ref26 rg17/ref17 rg8/ref8 rg2/ref2 rg25/ref25 Reinwald S. (rg20/ref20) 2004; 134 Watkins B.A. (rg31/ref31) 2000; 130 Weiss L.A. (rg35/ref35) 2005; 81 rg14/ref14 rg28/ref28 rg34/ref34 |
| References_xml | – ident: rg11/ref11 doi: 10.1038/427504a – ident: rg17/ref17 doi: 10.1159/isbn.978-3-318-04339-6 – ident: rg30/ref30 doi: 10.1016/j.appet.2009.03.007 – ident: rg32/ref32 doi: 10.1016/S0163-7827(00)00016-3 – ident: rg3/ref3 doi: 10.1016/j.plefa.2006.05.013 – ident: rg34/ref34 doi: 10.1016/j.jnutbio.2005.05.012 – ident: rg2/ref2 doi: 10.1007/BF02012794 – ident: rg16/ref16 doi: 10.1007/s11745-003-1115-8 – volume: 35 start-page: 306 issue: 3 year: 1983 ident: rg5/ref5 publication-title: Res. Vet. Sci. doi: 10.1016/S0034-5288(18)32024-1 – volume: 226 start-page: 497 issue: 1 year: 1957 ident: rg9/ref9 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)64849-5 – volume: 70 start-page: 560S issue: 3 year: 1999 ident: rg24/ref24 publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/70.3.560s – ident: rg29/ref29 doi: 10.1038/nrm2330 – ident: rg27/ref27 doi: 10.1017/S0029665100000021 – volume: 81 start-page: 934 issue: 4 year: 2005 ident: rg35/ref35 publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/81.4.934 – ident: rg28/ref28 doi: 10.1007/s11745-001-0798-1 – ident: rg12/ref12 doi: 10.1016/S0163-7827(97)00007-6 – ident: rg13/ref13 doi: 10.1016/j.appet.2008.01.005 – ident: rg33/ref33 doi: 10.1016/j.jnutbio.2005.01.019 – ident: rg36/ref36 doi: 10.1074/jbc.M707653200 – ident: rg4/ref4 – volume: 212 start-page: 573 issue: 3 year: 1983 ident: rg18/ref18 publication-title: Biochem. J. doi: 10.1042/bj2120573 – volume: 13 start-page: 1833 issue: 8 year: 2009 ident: rg19/ref19 publication-title: J. Cell. Mol. Med. doi: 10.1111/j.1582-4934.2008.00649.x – ident: rg26/ref26 doi: 10.1301/nr.2006.may.S24-S33 – ident: rg8/ref8 doi: 10.1007/s11745-999-0424-2 – ident: rg22/ref22 doi: 10.1079/BJN20051664 – volume: 19 start-page: 273 issue: 4 year: 1976 ident: rg1/ref1 publication-title: Calcif. Tissue Res. – volume: 134 start-page: 388 issue: 2 year: 2004 ident: rg20/ref20 publication-title: J. Nutr. doi: 10.1093/jn/134.2.388 – ident: rg25/ref25 doi: 10.1007/BF02534120 – volume: 130 start-page: 2274 issue: 9 year: 2000 ident: rg31/ref31 publication-title: J. Nutr. doi: 10.1093/jn/130.9.2274 – ident: rg15/ref15 doi: 10.3181/0808-RM-247 – ident: rg21/ref21 doi: 10.1111/j.1532-5415.2008.01870.x – ident: rg6/ref6 doi: 10.1016/0305-0491(83)90079-2 – volume: 211 start-page: 507 issue: 2 year: 1983 ident: rg10/ref10 publication-title: Biochem. J. doi: 10.1042/bj2110507 – ident: rg14/ref14 doi: 10.1016/j.jnutbio.2008.05.004 – ident: rg7/ref7 doi: 10.1038/nm1591 – ident: rg23/ref23 doi: 10.1007/s00223-007-9010-8 |
| SSID | ssib000828872 ssj0045063 |
| Score | 1.9872713 |
| Snippet | Dietary polyunsaturated fatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the fatty acid composition of membrane... Dietary polyunsaturated tatty acid (PUFA) incorporation into bone may alter its metabolism through changes in the Tally acid composition of membrane... |
| SourceID | proquest gale pubmed pascalfrancis crossref nrcresearch |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 447 |
| SubjectTerms | acides gras Age Animal experimentation Animal subjects Animals Biological and medical sciences Body Weight Bone cells Bone composition Bone Density bone development Bone mineral density Bones Chromatography densité minérale osseuse Diet Diets Docosahexaenoic acid Docosahexaenoic Acids - metabolism développement osseux Fatty acid composition Fatty Acid Transport Proteins - genetics Fatty Acid Transport Proteins - metabolism Fatty acids Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-6 - metabolism Female Femur Femur - metabolism Fundamental and applied biological sciences. Psychology Genes Genetic aspects Lecithin Lipids Liquid chromatography Liquids Lumbar Vertebrae - metabolism Male Measurement Metabolism Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Transgenic Mineralization Nutrition Oil Phosphatidylcholines - metabolism phosphatidylethanolamine Phosphatidylethanolamines - metabolism phosphatidylinositol Phosphatidylinositols - metabolism phosphatidylserine Phosphatidylserines - metabolism phospholipides Phospholipids Phospholipids - metabolism Physiological aspects Polyunsaturated fatty acids Proteins souris Spine Vertebrae Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports Weaning |
| Title | Fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids |
| URI | http://www.nrcresearchpress.com/doi/abs/10.1139/H10-029 https://www.ncbi.nlm.nih.gov/pubmed/20725110 https://www.proquest.com/docview/745960960 https://www.proquest.com/docview/748990228 https://www.proquest.com/docview/754885322 |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdge4EHNMpX2BiWQOOhCuTLSfrYMapqiL2w0fIUOY6jVurSak0fxl_Pne04jbYi4KFRFZ-SKPfz-c65-x0h72XByjgoUzdOSghQOBPuQMC84nEp00TEkYyxOPnbRTy-is6nbNp-wVfVJXX-Ufy6t67kf7QK50CvWCX7D5q1F4UT8B_0C0fQMBz_SscjXrs-NkGW2NEGG3EhYQMovuQ1ONdczFXNWpOYhY5hiZm1hh8AWzHjd-NFfzVbruG3mK_muvDXEtMaJ1VtgNjClqqh8G9yP69lDWBaNHSEishxo6AjVQsA2f_Ztz7zhOt0-omsitu2EuKr2bk-x82LabtTbjPv-xNTImE2KbZS5Bq7mvjMheneMbyap8QALNqyopEm4bxr3UMkRx3j5fU2yZaOV9dKyYGXYNDktcubTTpshh6S_SBJ8Jv-_vD07HTULNwR04337LPqGmu86ydzT6SONlfp-DFmNX9c3QjD0TTDJFu-hnlW6gYpuyMY5clcHpAnJgShQ42np-SBrHrEOZvLmp5QwxO7oBeNjnuk18YWIPFdfWR6Rn4o9FFEH7Xoo4A-qtBHEX10C310WVKDPgqYoRZ9tIO-5-Rq9OXy89g1XTpcAaFC7eZgxkt0BSGSTsNE5uCRpmUSCsCBAO86FRw8IHBkkfowCLjPRDAokpD5-SDnYRi-IHvVspKvCPXDAALqhMnIS8FI-APwJZOI8cLjRSq81CEnzTvPhKGwx04qi0yFsuEgAz1loCeHUCu40qwtd0XeotIyXW5srUE2RIZO3CSJHfJBSSDA4C6Cm4IVeFbkTOtIHnUkwUKLzvC7LWD84YHuk5rp0WxVlA457kDKykBUxCDOgfdz2GAsM2ZqncELRFbJ2IOXYkfxCTG7spLLDYqk4JQGeIGdIgxWegarv0NeavC2dzcz4vXOkUPyqDUKR2SvvtnIN-DL1_mxmYO_ASCW7lo |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fat-1+gene+modulates+the+fatty+acid+composition+of+femoral+and+vertebral+phospholipids&rft.jtitle=Applied+physiology%2C+nutrition%2C+and+metabolism&rft.au=Lau%2C+Beatrice+Y+Y&rft.au=Ward%2C+Wendy+E&rft.au=Kang%2C+Jing+X&rft.au=Ma%2C+David+W+L&rft.date=2010-08-01&rft.issn=1715-5312&rft.volume=35&rft.issue=4&rft.spage=447&rft_id=info:doi/10.1139%2FH10-029&rft_id=info%3Apmid%2F20725110&rft.externalDocID=20725110 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1715-5312&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1715-5312&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1715-5312&client=summon |