Microsatellite marker analysis of Haemonchus contortus populations from Pakistan suggests that frequent benzimidazole drug treatment does not result in a reduction of overall genetic diversity

• Published in: Parasites & vectors Vol. 9; no. 1; p. 349
• Main Authors: Chaudhry, Umer, Redman, E. M., Ashraf, Kamran, Shabbir, Muhammad Zubair, Rashid, Muhammad Imran, Ashraf, Shoaib, Gilleard, John S.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.06.2016; BioMed Central
• Subjects: adults; Animals; Anthelmintics - pharmacology; benzimidazole; Benzimidazoles; Benzimidazoles - pharmacology; Biological diversity; Cloning, Molecular; DNA, Helminth; Dosage and administration; drug therapy; drugs; farms; Forecasts and trends; Gene Expression Regulation - drug effects; Genetic aspects; genetic markers; genetic variation; Genetic Variation - drug effects; geographical distribution; Goat Diseases - drug therapy; Goat Diseases - epidemiology; Goat Diseases - parasitology; Goats; Haemonchus - drug effects; Haemonchus - genetics; Haemonchus contortus; haplotypes; herds; Identification and classification; loci; Microsatellite Repeats; Microsatellites (Genetics); mutation; Pakistan; Pakistan - epidemiology; parasites; Phylogeny; Selection, Genetic; sequence analysis; Sheep; Sheep Diseases - drug therapy; Sheep Diseases - epidemiology; Sheep Diseases - parasitology; small ruminants; tubulin; Tubulin - genetics; Tubulin - metabolism; Pakistan; Haemonchus contortus; Helminth; Albendazole; Anthelmintic; Benzimidazole; Genetic diversity; Drug resistance; Soft selective sweep; β-tubulin

The impact of drug selection pressure on the overall genetic diversity of parasitic nematode populations in the field is poorly understood. In this study, we address this issue for the small ruminant parasite Haemonchus contortus in the Punjab, Pakistan. This region provides an opportunity to compar...