Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels - Tradtrantip, Lukmanee; Namkung, Wan; Verkman, A.S. (Molecular pharmacology, 2010)
Keywords: 3-isobutyl-1-methylxanthine; Anoctamin-1; Antidiarrheals - pharmacology; CaCC; calcium-activated chloride channel; Cell Line; CFTR; CFTRinh-172; Chloride Channels - antagonists & inhibitors; chlorophenylthio-cAMP; CPT-cAMP; Croton - chemistry; cystic fibrosis transmembrane conductance regulator; Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors; Fisher rat thyroid; FRT; glycine hydrazide cystic fibrosis transmembrane conductance regulator inhibitor; GlyH-101; Humans; IBMX; Inhibitory Concentration 50; Intestinal Mucosa - metabolism; Membrane Proteins - antagonists & inhibitors; Membrane Transport Proteins - drug effects; N-methyl-d-glucamine chloride; Neoplasm Proteins - antagonists & inhibitors; NMDG-Cl; Proanthocyanidins - pharmacology; Proanthocyanidins - therapeutic use; Signal Transduction - drug effects; thiazolidinone cystic fibrosis transmembrane conductance regulator inhibitor; CaCC; GlyH-101; IBMX; CFTRinh-172; CPT-cAMP; FRT; CFTR; NMDG-Cl