Glutamate transporters: confining runaway excitation by shaping synaptic transmission

• Published in: Nature reviews. Neuroscience Vol. 8; no. 12; pp. 935 - 947
• Main Authors: Tzingounis, Anastassios V., Wadiche, Jacques I.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2007; Nature Publishing Group
• Subjects: Amino Acid Transport System X-AG - chemistry; Amino Acid Transport System X-AG - metabolism; Amino Acid Transport System X-AG - physiology; Analysis; Animal Genetics and Genomics; Animals; Behavioral Sciences; Binding sites; Biological and medical sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Cell-mediated cytotoxicity; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Cloning; Fundamental and applied biological sciences. Psychology; Genes; Glutamate; Glutamic Acid - chemistry; Glutamic Acid - metabolism; Glutamic Acid - physiology; Humans; Neural transmission; Neurobiology; Neuronal Plasticity - physiology; Neurosciences; Proteins; Regulation; review-article; Synaptic Transmission - physiology; Vertebrates: nervous system and sense organs; United States; United States > US; San Francisco California; California; Synaptic transmission; Excitatory aminoacid; Neurotransmitter; Review; Glutamatergic transmission; Glutamate; Carrier protein

Key Points Excitatory amino-acid transporters (EAATs) terminate glutamate's actions and thus maintain proper neuronal function. These proteins are expressed in vast quantities by glia, but are also present in neurons. Glutamate uptake is coupled to the cotransport of three Na + ions and one H +...