Drosophila Decapping Protein 1, dDcp1, Is a Component of the oskar mRNP Complex and Directs Its Posterior Localization in the Oocyte

• Published in: Developmental cell Vol. 10; no. 5; pp. 601 - 613
• Main Authors: Lin, Ming-Der, Fan, Shih-Jung, Hsu, Wei-Shan, Chou, Tze-Bin
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 01.05.2006; Cell Press
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Caspases; Cell differentiation, maturation, development, hematopoiesis; Cell physiology; Cytoplasm - metabolism; DEVBIO; DNA-Binding Proteins - metabolism; Drosophila; Drosophila melanogaster - cytology; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Egg Proteins - metabolism; Fundamental and applied biological sciences. Psychology; Genes, Insect - genetics; Microtubule-Associated Proteins - metabolism; Microtubules - metabolism; Molecular and cellular biology; Molecular Sequence Data; Oocytes - metabolism; Protein Transport; Ribonucleoproteins - chemistry; Ribonucleoproteins - metabolism; RNA; RNA Stability; RNA, Messenger - metabolism; RNA-Binding Proteins - metabolism; Sequence Alignment; Transcription Factors - metabolism; RNA; DEVBIO; Arthropoda; Insecta; Development; Germinal cell; Invertebrata; Localization; Drosophila melanogaster; Diptera; Oocyte; Protein; Drosophilidae
• ISSN: 1534-5807; 1878-1551
• DOI: 10.1016/j.devcel.2006.02.021

In Drosophila, posterior deposition of oskar ( osk) mRNA in oocytes is critical for both pole cell and abdomen formation. Exon junction complex components, translational regulation factors, and other proteins form an RNP complex that is essential for directing osk mRNA to the posterior of the oocyte...