The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance - Kumar, Vineet; Yin, Jia; Billington, Sarah; Prasad, Bhagwat; Brown, Colin D.A.; Wang, Joanne; Unadkat, Jashvant D. (Drug metabolism and disposition, 2018)
Keywords: Biological Transport; Biotinylation; Carbon 14; Cell Line; Epithelial cells; Humans; In vivo methods and tests; Kidney - metabolism; Kidney - physiology; Kidneys; Membrane potential; Membrane Potentials; Membranes; Metabolic Clearance Rate; Metformin; Metformin - metabolism; Oct-2 protein; Organic Cation Transporter 2 - metabolism; Plasma; Proteins; Proteomics; Renal cortex; CLr,sec; KRH; BCA; LC-MS/MS; sulfo-NHS-SS-Biotin; DTT; OCT2; IVIVE; SIL; DPBS