Association of distinct microbial and metabolic signatures with microscopic colitis

• Published in: NATURE COMMUNICATIONS Vol. 16; no. 1; pp. 4644 - 14
• Main Authors: Chen, Albert Sheng-Yin, Kim, Hanseul, Nzabarushimana, Etienne, Shen, Jiaxian, Williams, Katherine, Gurung, Jenny, McGoldrick, Jessica, Burke, Kristin E., Yarze, Joseph C., Nguyen, Long H., Staller, Kyle, Chung, Daniel C., Xavier, Ramnik J., Khalili, Hamed
• Format: Journal Article Publication
• Language: English
• Published: London Nature Publishing Group UK 23.05.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/107; 692/4020/1503; Adult; Aged; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Bacteria - metabolism; Biomarkers; Biomarkers - metabolism; Case-Control Studies; Colitis; Colitis, Microscopic - metabolism; Colitis, Microscopic - microbiology; Diarrhea; Diarrhea - metabolism; Diarrhea - microbiology; Digestive system; Feces - microbiology; Female; Gastrointestinal Microbiome - genetics; Gastrointestinal tract; Gene sequencing; High performance liquid chromatography; Humanities and Social Sciences; Humans; Inflammatory bowel disease; Inflammatory diseases; Intestinal microflora; Intestine; Large intestine; Liquid chromatography; Male; Mass spectrometry; Mass spectroscopy; Metabolic pathways; Metabolism; Metabolites; Metabolome; Metabolomics; Metagenomics; Microbiomes; Microorganisms; Middle Aged; multidisciplinary; Older people; Pathogenesis; Science; Science (multidisciplinary); Therapeutic targets

Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine that primarily affects older adults and presents with chronic diarrhea. The etiology is unknown and there are currently no FDA approved medications or biomarkers for treatment or monitoring of the disease. Emerging evi...