The Roles of Xenobiotic Receptors: Beyond Chemical Disposition

• Published in: Drug metabolism and disposition Vol. 46; no. 9; pp. 1361 - 1371
• Main Authors: Mackowiak, Bryan, Hodge, Jessica, Stern, Sydney, Wang, Hongbing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2018; American Society for Pharmacology and Experimental Therapeutics, Inc; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Cancer; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Constitutive Androstane Receptor; Drug metabolism; Energy balance; Energy Metabolism; Gene Expression Regulation, Neoplastic; Homeostasis; Humans; Immune clearance; Immune response; Immune system; Metabolism; Minireview; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Organic chemistry; Pregnane X Receptor - genetics; Pregnane X Receptor - metabolism; Proteins; Receptors; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Signal Transduction; Xenobiotics - metabolism; T4; NR; PEPCK; PGC1α; EGF; HFD; HCC; PXR; RXR; PB; G6Pase; CAR; miRNA; TCPOBOP; PCN; XR; DME; SGK2; WT; T3

Over the past 20 years, the ability of the xenobiotic receptors to coordinate an array of drug-metabolizing enzymes and transporters in response to endogenous and exogenous stimuli has been extensively characterized and well documented. The constitutive androstane receptor (CAR) and the pregnane X r...