Development and Validation of a New UFLC–MS/MS Method for the Detection of Organophosphate Pesticide Metabolites in Urine

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 15; p. 5800
• Main Authors: Kumar, Dileshwar, Sinha, Sukesh Narayan, Vasudev, Kasturi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2023; MDPI
• Subjects: Biological monitoring; biomarker; Biomarkers; Chromatography; Comparative analysis; DAP metabolites; Environmental impact; Health aspects; Humans; Insecticides - analysis; Laboratories; Liquid chromatography; Mass spectrometry; Metabolites; Methods; organophosphate pesticides; Organophosphates; Pesticides; Pesticides - analysis; Phosphates; Poisoning; Reproducibility of Results; Tandem Mass Spectrometry; UFLC–MS/MS; Urine; Israel; India; UFLC–MS/MS; DAP metabolites; biomarker; organophosphate pesticides; urine

To monitor human exposure to pesticides, experts commonly measure their metabolites in urine, particularly dialkyl phosphates (DAPs), which include diethyl phosphate (DEP), Diethyl thiophosphate (DETP), diethyl dithiophosphate (DEDTP), dimethyl phosphate (DMP), dimethyl thiophosphate (DMTP) and dime...