Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

• Published in: Nucleic acids research Vol. 35; no. 22; pp. 7497 - 7504
• Main Authors: Lovell, Mark A., Markesbery, William R.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2007; Oxford Publishing Limited (England)
• Subjects: acrolein; Aged; Aged, 80 and over; Aldehydes; Alzheimer disease; Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; byproducts; Chemical degradation; Cognition Disorders - diagnosis; Cognition Disorders - genetics; Cognitive ability; crosslinking; cytosine; DNA - chemistry; DNA - metabolism; DNA Damage; DNA Repair; guanine; hippocampus; Humans; Hydroxyl radicals; lipid peroxidation; Mitochondrial DNA; mutation; neurodegenerative diseases; nuclear genome; Oxidation-Reduction; Oxidative Stress; Peroxidation; Protein synthesis; Survey and Summary

Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer's disease (AD). Attack of DNA by reactive oxygen species (ROS), particularly hydroxyl radicals, can lead to strand breaks, DNA–DNA and DNA–protein cross-linking, and...