Regulation of the Antimicrobial Response by NLR Proteins

• Published in: Immunity (Cambridge, Mass.) Vol. 34; no. 5; pp. 665 - 679
• Main Authors: Elinav, Eran, Strowig, Till, Henao-Mejia, Jorge, Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.05.2011; Elsevier Limited
• Subjects: Adaptive Immunity; Animals; Antimicrobial agents; Autophagy; Bacteria; Bacterial Infections - genetics; Bacterial Infections - immunology; Cytokines; Gram-positive bacteria; Humans; Immune system; Immunity, Innate; Infections; Kinases; Ligands; Nod Signaling Adaptor Proteins - genetics; Nod Signaling Adaptor Proteins - immunology; Peptides; Proteins; Studies

Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family of innate immune receptors that play a pivotal role in microbial sensing, leading to the initiation of antimicrobial immune responses. Dysregulation of the function of multiple NLR family members has been link...