Weaver mutant mice exhibit long-term learning deficits under several measures of instrumental behavior

• Published in: Physiology & behavior Vol. 92; no. 5; pp. 1002 - 1009
• Main Authors: Derenne, Adam, Arsenault, Matthew L., Austin, David P., Weatherly, Jeffrey N.
• Format: Journal Article
• Language: English
• Published: Cambridge Elsevier Inc 05.12.2007; New York, NY Elsevier
• Subjects: Aging; Animals; Behavior; Behavior, Animal; Behavioral psychophysiology; Biological and medical sciences; Conditioning, Operant - physiology; Discrimination (Psychology); Dopamine; Fundamental and applied biological sciences. Psychology; Learning Disorders - genetics; Learning Disorders - physiopathology; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants - physiology; Parkinson's disease; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Reinforcement (Psychology); Reinforcement Schedule; Schedule of reinforcement; Stimulus discrimination; Weaver mutant mice; Parkinson's disease; Dopamine; Aging; Weaver mutant mice; Behavior; Schedule of reinforcement; Stimulus discrimination; Senescence; Parkinson disease; Learning; Acquisition process; Instrumental behavior; Learning disability; Reinforcement; Degenerative disease; Nervous system diseases; Rodentia; Instrumental conditioning; Catecholamine; Long term; Cerebral disorder; Vertebrata; Mammalia; Mouse; Animal; Central nervous system disease; Neurotransmitter; Extrapyramidal syndrome
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2007.07.015

Homozygous weaver mutant mice (wv/wv) exhibit symptoms that parallel Parkinson's disease, including motor deficits and the destruction of dopaminergic neurons as well as degeneration in the cerebellum and hippocampus. To develop a more complete behavioral profile of these organisms, groups of wv/wv, wv/+ mice and C57BL/6 mice were observed on a within-subjects basis under a fixed-interval schedule of reinforcement, a differential-reinforcement-of-low-rate-of-responding schedule, and a discrimination task in which a saccharin solution and tap water were concurrently available from two food cups. Under both reinforcement schedules, the wv/wv mice responded as frequently as the comparison subjects, but they responded in a manner that was inappropriate to the contingencies. Rather than respond with increasing frequency as the upcoming reinforcer became temporally proximate, wv/wv mice responded with decreasing probability as a function of the time since the previous reinforcer. Under the discrimination task, the wv/wv mice, unlike the controls, obtained saccharin over tap water at the level of chance. The findings suggest that weaver mutant mice express learning deficits similar to those found in other dopamine-deficient organisms.