Prefrontal Cortex Stimulation Enhances Fear Extinction Memory in Humans

• Published in: Biological psychiatry (1969) Vol. 84; no. 2; pp. 129 - 137
• Main Authors: Raij, Tommi, Nummenmaa, Aapo, Marin, Marie-France, Porter, Daria, Furtak, Sharon, Setsompop, Kawin, Milad, Mohammed R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.07.2018
• Subjects: Animals; Conditioning, Classical; Connectivity; Cortical map; Diffusion tensor imaging; Extinction, Psychological; Fear; Fear conditioning; Fear extinction; Humans; Magnetic Resonance Imaging; Mental Recall; Prefrontal Cortex - physiology; Psychiatric/Mental Health; Rats; Regression Analysis; TMS; Transcranial Magnetic Stimulation; Transcranial magnetic stimulation; Cortical map; Fear extinction; Connectivity; TMS; Diffusion tensor imaging; Fear conditioning
• ISSN: 0006-3223; 1873-2402; 1873-2402
• DOI: 10.1016/j.biopsych.2017.10.022

Animal fear conditioning studies have illuminated neuronal mechanisms of learned associations between sensory stimuli and fear responses. In rats, brief electrical stimulation of the infralimbic cortex has been shown to reduce conditioned freezing during recall of extinction memory. Here, we transla...