Cerebrospinal fluid-derived circulating tumor DNA is more comprehensive than plasma in NSCLC patients with leptomeningeal metastases regardless of extracranial evolution

• Published in: Heliyon Vol. 8; no. 12; p. e12374
• Main Authors: Yang, Hainan, Wen, Lei, Zhao, Chao, Chen, Jianing, Zhou, Zhaoming, Zhou, Cheng, Cai, Linbo, Zhou, Caicun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2022; Elsevier
• Subjects: Brain metastases; Cerebrospinal fluid; Leptomeningeal metastases; Next-generation sequencing; Systemic disease progression; Brain metastases; Next-generation sequencing; Cerebrospinal fluid; Systemic disease progression; Leptomeningeal metastases

Metastases to the central nervous system (CNS) are devastating neurological complications. Circulating cell-free tumor DNA (ctDNA) from cerebrospinal fluid (CSF) better represents genomic alterations in CNS tumors compared to plasma (PLA). However, the clinical value of cerebrospinal fluid (CSF) as...