Expression of the ubiquitin-proteasome pathway and muscle loss in experimental cancer cachexia

• Published in: British journal of cancer Vol. 93; no. 7; pp. 774 - 780
• Main Authors: KHAL, J, WYKE, S. M, RUSSELL, S. T, HINE, A. V, TISDALE, M. J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 03.10.2005
• Subjects: Animals; Base Sequence; Biological and medical sciences; Blotting, Western; Cachexia - complications; Cachexia - enzymology; Cachexia - metabolism; Cachexia - physiopathology; Cancer research; DNA Primers; Medical research; Medical sciences; Mice; Muscle, Skeletal - enzymology; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Musculoskeletal system; Neoplasms, Experimental - complications; Neoplasms, Experimental - enzymology; Neoplasms, Experimental - metabolism; Neoplasms, Experimental - physiopathology; Proteasome Endopeptidase Complex - metabolism; Protein synthesis; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Translational Therapeutics; Tumors; Ubiquitin - metabolism; Ubiquitin; Multicatalytic endopeptidase complex; Enzyme; Cachexia; Malignant tumor; ubiquitin-proteasome proteolysis; Protein; Degradation; Peptidases; Cancerology; Proteolysis; Hydrolases; Muscle; gastrocnemius muscle; protein degradation

Muscle protein degradation is thought to play a major role in muscle atrophy in cancer cachexia. To investigate the importance of the ubiquitin-proteasome pathway, which has been suggested to be the main degradative pathway mediating progressive protein loss in cachexia, the expression of mRNA for p...