Modulation of the default mode network is task-dependant in chronic schizophrenia patients

• Published in: Schizophrenia research Vol. 125; no. 2; pp. 110 - 117
• Main Authors: Schneider, Fabien C., Royer, Aurélie, Grosselin, Anne, Pellet, Jacques, Barral, Fabrice-Guy, Laurent, Bernard, Brouillet, Denis, Lang, François
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.02.2011; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Attention - physiology; Biological and medical sciences; Brain - pathology; Brain - physiopathology; Brain Mapping - methods; Chronic Disease; Default mode network; Dominance, Cerebral - physiology; Female; fMRI; Humanities and Social Sciences; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Medical sciences; Memory, Short-Term - physiology; Nerve Net - physiopathology; Neural Inhibition - physiology; Neuropsychological Tests; Posterior cingulate cortex; Problem Solving - physiology; Psychiatric/Mental Health; Psychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Reaction Time - physiology; Schizophrenia; Schizophrenia - pathology; Schizophrenia - physiopathology; Schizophrenic Psychology; Semantics; Task-induced deactivations; Verbal Learning - physiology; Schizophrenia; fMRI; Default mode network; Task-induced deactivations; Posterior cingulate cortex; Human; Deactivation; Central nervous system; Nuclear magnetic resonance imaging; Encephalon; Psychosis; Chronic; Cingulate cortex; Medical imagery; Functional imaging

The activity of brain regions of the so-called default mode network (DMN) attenuates during the performance of goal-directed tasks. These activity decreases (named task-induced deactivations; TID) are though to reflect the reallocation of cognitive resources from the DMN to areas implicated in the e...