Circuits and functions of the lateral habenula in health and in disease

• Published in: Nature reviews. Neuroscience Vol. 21; no. 5; pp. 277 - 295
• Main Authors: Hu, Hailan, Cui, Yihui, Yang, Yan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2020; Nature Publishing Group
• Subjects: 631/378/1689/1414; 631/378/1788; 631/378/3920; Animal Genetics and Genomics; Animal models; Animals; Basal ganglia; Basal Ganglia - physiology; Basal Ganglia - physiopathology; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Circuits; Cognitive ability; Dopamine receptors; Forebrain; Habenula; Habenula - physiology; Habenula - physiopathology; Health; Health aspects; Humans; Limbic System - physiology; Limbic System - physiopathology; Luteinizing hormone; Major depressive disorder; Mental depression; Mental disorders; Mental Disorders - physiopathology; Mesencephalon; Mesencephalon - physiology; Mesencephalon - physiopathology; Motivation; Neural circuitry; Neural networks; Neural Pathways - physiology; Neural Pathways - physiopathology; Neurobiology; Neurophysiology; Neurosciences; Norepinephrine; Review Article; Risk factors; Withdrawal; China

The past decade has witnessed exponentially growing interest in the lateral habenula (LHb) owing to new discoveries relating to its critical role in regulating negatively motivated behaviour and its implication in major depression. The LHb, sometimes referred to as the brain’s ‘antireward centre’, r...