The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

• Published in: Immunity (Cambridge, Mass.) Vol. 33; no. 5; pp. 765 - 776
• Main Authors: Tsuchida, Tetsuo, Zou, Jian, Saitoh, Tatsuya, Kumar, Himanshu, Abe, Takayuki, Matsuura, Yoshiharu, Kawai, Taro, Akira, Shizuo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.11.2010; Elsevier Limited
• Subjects: Cloning; Cytosol; Deoxyribonucleic acid; DNA; DNA - immunology; Gene expression; HEK293 Cells; HeLa Cells; Humans; Immune system; Immunity, Innate; Interferon-beta - immunology; Interferon-beta - metabolism; Kinases; Lysine - metabolism; Membrane Proteins - metabolism; Plasmids; Promoter Regions, Genetic; Protein-Serine-Threonine Kinases - immunology; Protein-Serine-Threonine Kinases - metabolism; RNA polymerase; Rodents; Signal transduction; Tripartite Motif Proteins; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination - immunology

The innate immune system detects pathogen- and host-derived double-stranded DNA exposed to the cytosol and induces type I interferon (IFN) and other cytokines. Here, we identified interferon-inducible tripartite-motif (TRIM) 56 as a regulator of double-stranded DNA-mediated type I interferon inducti...