Regional Characteristics of [125I] Cholecystokinin Octapeptide Specific Binding to Rat Brain Membranes Following 6-Hydroxydopamine Treatment
The relative changes in the amount of specific [125I] cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine (6-OHDA) treatment were examined. The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day afte...
Saved in:
| Published in | Biological & pharmaceutical bulletin Vol. 18; no. 3; pp. 416 - 420 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
The Pharmaceutical Society of Japan
1995
Maruzen |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0918-6158 1347-5215 |
| DOI | 10.1248/bpb.18.416 |
Cover
| Abstract | The relative changes in the amount of specific [125I] cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine (6-OHDA) treatment were examined. The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day after 6-OHDA treatment. Thereafter, the specific binding recovered to 60% and 65% of control values in the frontal cortex and striatum respectively on the 28th day. On the other hand, in the nucleus accumbens, where CCK8 co-exists in the dopamine neuron, the specific binding decreased gradually, and its recovery was delayed compared with that of the frontal cortex and striatum. In the hippocampus, 6-OHDA treatment had no effect on the specific binding throughout the experimental period. The decrease of [125I] CCK8-specific binding could be caused by enhanced release of CCK8 in the frontal cortex, striatum, and nucleus accumbens, and the recovery of specific binding could be induced by depletion of CCK8 in nerve terminals. Particularly in the nucleus accumbens, the delayed recovery of specific binding suggests the loss of the pre-synaptic binding site, which exists in the CCK8/DA co-existing neuron, together with a change in CCK8 release. |
|---|---|
| AbstractList | The relative changes in the amount of specific [125I]cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine (6-OHDA) treatment were examined. The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day after 6-OHDA treatment. Thereafter, the specific binding recovered to 60% and 65% of control values in the frontal cortex and striatum respectively on the 28th day. On the other hand, in the nucleus accumbens, where CCK8 co-exists in the dopamine neuron, the specific binding decreased gradually, and its recovery was delayed compared with that of the frontal cortex and striatum. In the hippocampus, 6-OHDA treatment had no effect on the specific binding throughout the experimental period. The decrease of [125I]CCK8-specific binding could be caused by enhanced release of CCK8 in the frontal cortex, striatum, and nucleus accumbens, and the recovery of specific binding could be induced by depletion of CCK8 in nerve terminals. Particularly in the nucleus accumbens, the delayed recovery of specific binding suggests the loss of the pre-synaptic binding site, which exists in the CCK8/DA co-existing neuron, together with a change in CCK8 release. The relative changes in the amount of specific [ super(125)I]cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine (6-OHDA) treatment were examined. The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day after 6-OHDA treatment. Thereafter, the specific binding recovered to 60% and 65% of control values in the frontal cortex and striatum respectively on the 28th day. On the other hand, in the nucleus accumbens, where CCK8 co-exists in the dopamine neuron, the specific binding decreased gradually, and its recovery was delayed compared with that of the frontal cortex and striatum. In the hippocampus, 6-OHDA treatment had no effect on the specific binding throughout the experimental period. The decrease of [ super(125)I]CCK8-specific binding could be caused by enhanced release of CCK8 in the frontal cortex, striatum, and nucleus accumbens, and the recovery of specific binding could be induced by depletion of CCK8 in nerve terminals. Particularly in the nucleus accumbens, the delayed recovery of specific binding suggests the loss of the pre-synaptic binding site, which exists in the CCK8/DA co-existing neuron, together with a change in CCK8 release. |
| Author | MIYAKE, Katsushi KITAURA, Teruaki KIMURA, Yasuhiro KIHIRA, Kenji FUKUCHI, Hiroshi |
| Author_xml | – sequence: 1 fullname: MIYAKE, Katsushi – sequence: 1 fullname: KIHIRA, Kenji – sequence: 1 fullname: KITAURA, Teruaki – sequence: 1 fullname: KIMURA, Yasuhiro – sequence: 1 fullname: FUKUCHI, Hiroshi |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3574839$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/7550094$$D View this record in MEDLINE/PubMed |
| BookMark | eNo90U1rFDEYB_AglbqtXrwLOYgHYdY8k8m8HO1ibaFSqPUkMuTlmTV1JhmTLLrfwQ9tlh32khz-v4Qn-V-QM-cdEvIa2BrKqv2gZrWGdl1B_YysgFdNIUoQZ2TFOmiLGkT7glzE-MQYa1jJz8l5IwRjXbUi_x5wa72TI938lEHqhMHGZHWkfqDfoRS3P3LiR9T7mPwv66yj9zrJGedkDdKvM2o7WE2vrDPWbWny9EEmehVkll9wUkE6jPTaj6P_cwB1cbM3wf_dGz_LyTqkjwFlmtCll-T5IMeIr5b9kny7_vS4uSnu7j_fbj7eFVpwngpQLZhmyPNzXinNzFByjdhoIZTQRpuGd2zAWoOQiqEErgE7ZaqyxEoZxi_Ju-O9c_C_dxhTP9mocRzzqH4Xe6i7uqwbyPDNAndqQtPPwU4y7Pvl-3L-dsll1HIc8lu1jSfGRVO1vMvs_ZHp4GMMOJwEsP7QYJ8b7KHtc4MZb474KSa5xROVIdcy4oFC1_EDX5Z86pTq3GKPjv8H8ySoGA |
| ContentType | Journal Article |
| Copyright | The Pharmaceutical Society of Japan 1995 INIST-CNRS |
| Copyright_xml | – notice: The Pharmaceutical Society of Japan – notice: 1995 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7TK |
| DOI | 10.1248/bpb.18.416 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Neurosciences Abstracts |
| DatabaseTitleList | MEDLINE Neurosciences Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1347-5215 |
| EndPage | 420 |
| ExternalDocumentID | 7550094 3574839 10_1248_bpb_18_416 article_bpb1993_18_3_18_3_416_article_char_en |
| Genre | Journal Article |
| GroupedDBID | --- .55 2WC 53G 5GY 6J9 ACGFO ACIWK ACPRK ADBBV AENEX AFFNX AFRAH AI. ALMA_UNASSIGNED_HOLDINGS BAWUL CS3 DIK DU5 E3Z EBS EJD F5P GX1 HH5 JSF JSH KQ8 OK1 P2P RJT RZJ TKC TR2 VH1 X7M ZXP 1CY 23N AAYXX ABJNI BKOMP CITATION JMI MOJWN XSB ZY4 IQODW ABTAH CGR CUY CVF ECM EIF NPM 7TK |
| ID | FETCH-LOGICAL-c533t-1b81d7f094334bc0df23cee7c55b5cdcd7390fe6c15ab0ea13c1e9bd422e4bd03 |
| ISSN | 0918-6158 |
| IngestDate | Fri Jul 11 09:23:41 EDT 2025 Sat Sep 28 08:35:48 EDT 2024 Mon Jul 21 09:15:07 EDT 2025 Tue Jul 01 02:29:10 EDT 2025 Wed Sep 03 06:32:31 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Rat Peptide hormone Rodentia Neuropeptide In vitro Vertebrata Biological fixation Gastrointestinal hormone Mammalia Animal Membrane Cholecystokinin Brain (vertebrata) |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c533t-1b81d7f094334bc0df23cee7c55b5cdcd7390fe6c15ab0ea13c1e9bd422e4bd03 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/bpb1993/18/3/18_3_416/_article/-char/en |
| PMID | 7550094 |
| PQID | 16962671 |
| PQPubID | 23462 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_16962671 pubmed_primary_7550094 pascalfrancis_primary_3574839 crossref_primary_10_1248_bpb_18_416 jstage_primary_article_bpb1993_18_3_18_3_416_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1995-00-00 |
| PublicationDateYYYYMMDD | 1995-01-01 |
| PublicationDate_xml | – year: 1995 text: 1995-00-00 |
| PublicationDecade | 1990 |
| PublicationPlace | Tokyo |
| PublicationPlace_xml | – name: Tokyo – name: Japan |
| PublicationTitle | Biological & pharmaceutical bulletin |
| PublicationTitleAlternate | Biol Pharm Bull |
| PublicationYear | 1995 |
| Publisher | The Pharmaceutical Society of Japan Maruzen |
| Publisher_xml | – name: The Pharmaceutical Society of Japan – name: Maruzen |
| References | 23) G. Jonson, Ann. Rev. Neurosci., 3, 169 (1980). 20) F. Fukamauchi, T. Yoshikawa, S. Kaneno, H. Shibuya, R. Takahashi, Neuropeptides, 10, 221 (1987). 17) Y. Takeda, M. Hoshino, N. Yanaihara, C. Yanaihara, J. Isobe, N. Sugiura, K. Kashimoto, Y. Takano, H. Kamiya, Jpn. J. Pharmacol., 49, 471 (1989). 9) M.Z. Zigmond, T.W. Berger, A.A. Grace, E.M. Stricker, Mol. Chem. Neuropathol., 10, 185 (1989). 30) P. Gaudreau, S. St.-Pierre, C. Pert, R. Quirion, Ann. N.Y. Acad. Sci., 448, 198 (1985). 8) Y. Kimura, K. Miyake, T. Kitaura, K. Kihira, H. Fukuchi, Biol. Pharm. Bull., 17, 1210 (1994). 15) M. Praissman, P.A. Martinez, C.F. Saladio, J.M. Berkowitz, A.W. Steggles, J.A. Finkelstein, J. Neurochem., 40, 1406 (1983). 22) G.R. Breeze, T.D. Traylor, Br. J. Pharmacol., 42, 88 (1971). 28) H. Sankaran, .I.D. Goldfine, C.W. Deveney, K.Y. Wong, J.A. Williams, J. Biol. Chem., 254, 9349 (1980). 25) O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall, J. Biochem., 193, 265 (1951). 7) T. Hokfelt, J.F. Rehfeld, L. Skirboll, B. Ivemark, M. Goldstein, K. Markey, Nature (London), 285, 476 (1980). 4) J.E. Muller, E. Straus, R. Yalow, Proc. Natl. Acad. Sci. U.S.A., 74, 3035 (1977). 3) G.J. Dockray, Nature (London), 264, 568 (1976). 6) J.B. Hutchinson, J. Strupish, S.R. Nahorski, Brain Res., 370, 310 (1986). 2) V. Mutt, J.E. Jorpes, Eur. J. Biochem., 6, 156 (1968). 10) Y. Kimura, K. Kihira, K. Miyake, T. Kitaura, H. Fukuchi, Biol. Pharm. Bull., 18, 13 (1995). 12) S.P. Butcher, A. Varro, J.S. Kelly, G.J. Dockray, Brain Res., 505, 119 (1989). 18) A. Saito, H. Sankaran, I.D. Goldfine, J.A. Williams, Science, 208, 1155 (1980). 24) J. Glowinski, L.L. Iversen, J. Neurochem., 13, 655 (1966). 13) A. Saito, I.D. Goldfine, J.A. Williams, J. Neurochem., 37, 483 (1981). 21) G. Paxinos, C. Watson, "The Rat Brain in Stereotaxic Coordinates," 2nd ed., Academic Press, New York, 1986. 26) J.H. Falon, K.M. Serroogy, Ann. N.Y. Acad. Sci., 448, 121 (1985). 27) D.K. Meyer, Z. Protopapas, Ann. N.Y. Acad. Sci., 448, 133 (1985). 29) T.H. Moran, P.H. Robinson, M.S. Goldrich, P.R. McHugh, Brain Res., 362, 175 (1986). 5) P. Fray, Eur. J. Phamacol., 95, 87 (1983). 1) A.C. Ivy, E. Oldberg, Am. J. Physiol., 85, 381 (1928). 11) U. Conzelmann, A. Holland, D. Meyer, Eur. J. Pharmacol., 101, 119 (1984). 14) R.S.L. Chang, V.J. Lotti, G.E. Martin, T.B. Chen, Life Sci., 32, 871 (1983). 19) R. Sekiguchi, T. Moroji, Brain. Res., 399, 271 (1986). 16) C.W. Lin, T. Miller, J. Pharmacol. Exp. Ther., 232, 775 (1985). |
| References_xml | – reference: 4) J.E. Muller, E. Straus, R. Yalow, Proc. Natl. Acad. Sci. U.S.A., 74, 3035 (1977). – reference: 9) M.Z. Zigmond, T.W. Berger, A.A. Grace, E.M. Stricker, Mol. Chem. Neuropathol., 10, 185 (1989). – reference: 25) O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall, J. Biochem., 193, 265 (1951). – reference: 8) Y. Kimura, K. Miyake, T. Kitaura, K. Kihira, H. Fukuchi, Biol. Pharm. Bull., 17, 1210 (1994). – reference: 22) G.R. Breeze, T.D. Traylor, Br. J. Pharmacol., 42, 88 (1971). – reference: 2) V. Mutt, J.E. Jorpes, Eur. J. Biochem., 6, 156 (1968). – reference: 30) P. Gaudreau, S. St.-Pierre, C. Pert, R. Quirion, Ann. N.Y. Acad. Sci., 448, 198 (1985). – reference: 6) J.B. Hutchinson, J. Strupish, S.R. Nahorski, Brain Res., 370, 310 (1986). – reference: 18) A. Saito, H. Sankaran, I.D. Goldfine, J.A. Williams, Science, 208, 1155 (1980). – reference: 19) R. Sekiguchi, T. Moroji, Brain. Res., 399, 271 (1986). – reference: 26) J.H. Falon, K.M. Serroogy, Ann. N.Y. Acad. Sci., 448, 121 (1985). – reference: 3) G.J. Dockray, Nature (London), 264, 568 (1976). – reference: 10) Y. Kimura, K. Kihira, K. Miyake, T. Kitaura, H. Fukuchi, Biol. Pharm. Bull., 18, 13 (1995). – reference: 23) G. Jonson, Ann. Rev. Neurosci., 3, 169 (1980). – reference: 16) C.W. Lin, T. Miller, J. Pharmacol. Exp. Ther., 232, 775 (1985). – reference: 14) R.S.L. Chang, V.J. Lotti, G.E. Martin, T.B. Chen, Life Sci., 32, 871 (1983). – reference: 27) D.K. Meyer, Z. Protopapas, Ann. N.Y. Acad. Sci., 448, 133 (1985). – reference: 5) P. Fray, Eur. J. Phamacol., 95, 87 (1983). – reference: 21) G. Paxinos, C. Watson, "The Rat Brain in Stereotaxic Coordinates," 2nd ed., Academic Press, New York, 1986. – reference: 24) J. Glowinski, L.L. Iversen, J. Neurochem., 13, 655 (1966). – reference: 13) A. Saito, I.D. Goldfine, J.A. Williams, J. Neurochem., 37, 483 (1981). – reference: 28) H. Sankaran, .I.D. Goldfine, C.W. Deveney, K.Y. Wong, J.A. Williams, J. Biol. Chem., 254, 9349 (1980). – reference: 29) T.H. Moran, P.H. Robinson, M.S. Goldrich, P.R. McHugh, Brain Res., 362, 175 (1986). – reference: 1) A.C. Ivy, E. Oldberg, Am. J. Physiol., 85, 381 (1928). – reference: 15) M. Praissman, P.A. Martinez, C.F. Saladio, J.M. Berkowitz, A.W. Steggles, J.A. Finkelstein, J. Neurochem., 40, 1406 (1983). – reference: 17) Y. Takeda, M. Hoshino, N. Yanaihara, C. Yanaihara, J. Isobe, N. Sugiura, K. Kashimoto, Y. Takano, H. Kamiya, Jpn. J. Pharmacol., 49, 471 (1989). – reference: 7) T. Hokfelt, J.F. Rehfeld, L. Skirboll, B. Ivemark, M. Goldstein, K. Markey, Nature (London), 285, 476 (1980). – reference: 20) F. Fukamauchi, T. Yoshikawa, S. Kaneno, H. Shibuya, R. Takahashi, Neuropeptides, 10, 221 (1987). – reference: 12) S.P. Butcher, A. Varro, J.S. Kelly, G.J. Dockray, Brain Res., 505, 119 (1989). – reference: 11) U. Conzelmann, A. Holland, D. Meyer, Eur. J. Pharmacol., 101, 119 (1984). |
| SSID | ssj0007023 |
| Score | 1.4456334 |
| Snippet | The relative changes in the amount of specific [125I] cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine... The relative changes in the amount of specific [125I]cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine... The relative changes in the amount of specific [ super(125)I]cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after... |
| SourceID | proquest pubmed pascalfrancis crossref jstage |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 416 |
| SubjectTerms | 6-hydroxydopamine (6-OHDA) [125I] CCK8-specific binding Animals Biological and medical sciences Brain - drug effects Brain - metabolism CCK8/DA co-existing neuron Cerebral Cortex - drug effects Cerebral Cortex - metabolism cholecystokinin octapeptide (CCK8) dopamine (DA) Frontal Lobe - drug effects Frontal Lobe - metabolism Iodine Radioisotopes Kinetics Male Medical sciences Membrane Proteins - metabolism Membrane Proteins - pharmacology Membranes - drug effects Membranes - metabolism Miscellaneous Nerve Endings - metabolism Neuropharmacology Oxidopamine - pharmacology Pharmacology. Drug treatments Radioligand Assay Rats Rats, Wistar Sensitivity and Specificity Sincalide - immunology Sincalide - metabolism |
| Title | Regional Characteristics of [125I] Cholecystokinin Octapeptide Specific Binding to Rat Brain Membranes Following 6-Hydroxydopamine Treatment |
| URI | https://www.jstage.jst.go.jp/article/bpb1993/18/3/18_3_416/_article/-char/en https://www.ncbi.nlm.nih.gov/pubmed/7550094 https://www.proquest.com/docview/16962671 |
| Volume | 18 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Biological and Pharmaceutical Bulletin, 1995/03/15, Vol.18(3), pp.416-420 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKQAIJIdiYKDCwBJpAW0qcOEkr8VKqTS1ogKZOGk9R7DgsQ2uqNhUqf4FfxT_jHDt1egFp8GJVsY97OV_PxT4XQl52QOllLEmclIXSAY0HfynJueMDoHlbBH6o8Eb35GPYP-Pvz4PzRuPXUtTSrBQt-eOPeSX_w1V4BnzFLNl_4KzdFB7Aa-AvjMBhGK_F41P11Zzk9dbKLoMFiAWYvGAAnn5Pt8Cdg5X3DbtBHHySZTLGYJZUmfbzWS4P3uUmvQVM0VN9ZpDkeItzBc40CMODY4BL8R0XhE5_nmLsSwru9hXaqMNFrPrKBXFupSqCa3yxcnQulot-o7gfnJyddrU6SKazi3xS1DP9gZkBlXCZW3wMvnQ_HFXhINPZ9CKvCYbdaq-hmszAQK4PNjBRfPlskrXBpzU13VvKSGafR-A1m9zPTdFde_ZaDnMWLql0rvPtNrWFxzEDQoxFi7VblmS5JPeaqrQBjOg6AXUMtDFrx0B7g9z0oojpQsP92gOLXN1h0H6jqkIu0L6p33fFJrp1CW4B1nu4O06mwJLMNFj5uwekLaHhfXKvcmFo1-DxAWmo0TbZ6Y6Ssria032qg4r1bc02ud1bNBTcJvufDQjmh3RYZ_1NDzWJLaA-3yE_F7ima7imRUZfIapfr2GaLmGaLjBNK0zTsqCAaaoxTS2mqcU03cA0tZh-SM6Oj4a9vlM1DXEkeC6lwwR4YFGGAbM-F9JNM88HQzCSQSACmco08jtupkLJgkS4KmG-ZKojUu55iovU9XfJ1qgYqUeEesLlMg1ZW0YpV24Kukp6Xtb2Mj_Blt1N8mLBtnhsasPEm8BokreGo3ZNJS9wDYbP4rpqgOV2FrMuQcg1yd4KDuwufgDC1O80yfMFLmLgJ173wW9YzKYxCzuhF0asSXYNXCxpFAQYUfz4Wp__CbljyjjgseNTslVOZmoPDPFSPNNQ_w3yKeQU |
| linkProvider | ABC ChemistRy |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regional+Characteristics+of+%28125I%29Cholecystokinin+Octapeptide+Specific+Binding+to+Rat+Brain+Membranes+Following+6-Hydroxydopamine+Treatment&rft.jtitle=Biological+%26+pharmaceutical+bulletin&rft.au=KIMURA%2C+Yasuhiro&rft.au=KIHIRA%2C+Kenji&rft.au=MIYAKE%2C+Katsushi&rft.au=KITAURA%2C+Teruaki&rft.date=1995&rft.issn=0918-6158&rft.eissn=1347-5215&rft.volume=18&rft.issue=3&rft.spage=416&rft.epage=420&rft_id=info:doi/10.1248%2Fbpb.18.416&rft.externalDBID=n%2Fa&rft.externalDocID=10_1248_bpb_18_416 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0918-6158&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0918-6158&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0918-6158&client=summon |