Dual inhibitors of P-glycoprotein and tumor cell growth: (Re)discovering thioxanthones - Palmeira, Andreia; Vasconcelos, M. Helena; Paiva, Ana; Fernandes, Miguel X.; Pinto, Madalena; Sousa, Emília (Biochemical pharmacology, 2012)
Keywords: antagonists & inhibitors; Anticancer; anticarcinogenic activity; Antineoplastic Agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors; ATP-Binding Cassette, Sub-Family B, Member 1 - physiology; Biological and medical sciences; cell growth; chemistry; doxorubicin; Drug Discovery; Drug Discovery - trends; Dual ligands; Growth Inhibitors; Growth Inhibitors - chemistry; Growth Inhibitors - pharmacology; growth retardation; Humans; K562 Cells; leukemia; Medical sciences; microwave treatment; Multidrug resistance; P-glycoprotein; pharmacology; Pharmacology. Drug treatments; physiology; Thioxanthenes; Thioxanthenes - chemistry; Thioxanthenes - pharmacology; Thioxanthones; trends; verapamil; Xanthones; Xanthones - chemistry; Xanthones - pharmacology; ABC; SRB; P-gp; Multidrug resistance; MRP; MW; RMSD; TMD; MRP-1; Thioxanthones; Rh123; P-glycoprotein; MFI; NBD; SE; GI 50; DNA; Dual ligands; TM; MDR; RLU; Anticancer; ATP; BLAST; Antineoplastic agent; Cell proliferation; Treatment resistance; Ligand; P Glycoprotein; Malignant tumor; Tumor growth; Multiple resistance; Inhibitor; Tumor cell; Cancer