Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

• Published in: Biological psychiatry (1969) Vol. 84; no. 9; pp. 644 - 654
• Main Authors: Walton, Esther, Jiang, Wenhao, Yao, Nailin, Fukunaga, Masaki, Hashimoto, Ryota, Okada, Naohiro, Bustillo, Juan R., de Zwarte, Sonja M.C., Hulshoff Pol, Hilleke E., Andreassen, Ole A., Dale, Anders M., Doan, Nhat Trung, Gurholt, Tiril P., Hartberg, Cecilie B., Jørgensen, Kjetil N., Melle, Ingrid, Westlye, Lars T., Gruber, Oliver, Kraemer, Bernd, Tordesillas-Gutiérrez, Diana, Fullerton, Janice M., Green, Melissa J., Henskens, Frans A., Quidé, Yann, Schall, Ulrich, Scott, Rodney J., Cairns, Murray J., Tooney, Paul A., Rasser, Paul E., Cooper, Gavin, Morris, Derek W., Hong, Elliot, Gur, Ruben C., Satterthwaite, Theodore D., Wolf, Daniel H., Mathalon, Daniel H., Potkin, Steven G., Preda, Adrian, Voyvodic, James, Lim, Kelvin O., McEwen, Sarah, Tan, Yunlong, Fan, Fengmei, Guo, Hua, Wan, Ping, Bockholt, Henry J., Ehrlich, Stefan, Wolthusen, Rick P.F., King, Margaret D., De Haan, Lieuwe, de Rossi, Pietro, Iorio, Mariangela, McKenna, Peter J., Pomarol-Clotet, Edith, Kelly, Sinead, Whelan, Christopher D., Voineskos, Aristotle N., Ciufolini, Simone, Radua, Joaquim, Dazzan, Paola, Murray, Robin, Reis Marques, Tiago, Simmons, Andrew, Egloff, Laura, Harrisberger, Fabienne, Riecher-Rössler, Anita, Alpert, Kathryn I., Koops, Sanne, Bertolino, Alessandro, Bonvino, Aurora, Di Giorgio, Annabella, Stephen, Julia M., Cannon, Dara M., McDonald, Colm, Lebedeva, Irina, Tomyshev, Alexander S., Akhadov, Tolibjohn, Farde, Lars, Flyckt, Lena, Erhardt, Sophie, Schwieler, Lilly, Agartz, Ingrid, Collste, Karin, Victorsson, Pauliina, Orhan, Funda, Busatto, Geraldo F., Rosa, Pedro G.P., Zanetti, Marcus V., Skoch, Antonin, Spaniel, Filip, Tomecek, David, Hagenaars, Saskia P., McIntosh, Andrew M., Oertel-Knöchel, Viola, Uhlmann, Anne, Lopez-Jaramillo, Carlos, McMahon, Agnes, Faskowitz, Joshua I., Thompson, Paul M., Turner, Jessica A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018; Elsevier Science
• Subjects: Adolescent; Adult; Age of Onset; Aged; Brain - diagnostic imaging; Brain - pathology; Case-Control Studies; Child; Cortical; Female; Frontal Lobe - diagnostic imaging; Frontal Lobe - pathology; Humans; Imaging; Linear Models; Magnetic Resonance Imaging; Male; Meta-analysis; Middle Aged; Neuroimaging; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - pathology; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - pathology; Severity of Illness Index; Surface area; Temporal Lobe - diagnostic imaging; Temporal Lobe - pathology; Thickness; Young Adult; Thickness; Schizophrenia; Surface area; Cortical; Imaging; Meta-analysis

The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (E...