Synthesis of sulfadimethoxine based surfactants and their evaluation as antitumor agents

• Published in: Journal of cancer research and therapeutics Vol. 12; no. 1; pp. 137 - 141
• Main Authors: Khowdiary, Manal, Mostafa, Nashwa
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow Publications 01.01.2016; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd
• Subjects: Adsorption; Alcohol; Antibacterial agents; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cancer treatment; Cobalt; Cobalt - administration & dosage; Cobalt - chemistry; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; Cytotoxicity; Drug dosages; Ethanol; Expected values; Female; HCT116 Cells; Humans; MCF-7 Cells; Methods; Platinum - administration & dosage; Platinum - chemistry; Sulfadimethoxine - administration & dosage; Sulfadimethoxine - chemical synthesis; Sulfadimethoxine - chemistry; Surface active agents; Surface-Active Agents - administration & dosage; Surface-Active Agents - chemical synthesis; Surface-Active Agents - chemistry; Surfactants; Testing; Tumors; Antitumor complexes; aromatic diamines; critical micelle concentration

Aim of the Study: Synthesized CO (II) and Pt (II) of sulfadimethoxine. These compounds were tested for potential antitumor activity against two of human tumor cell lines, colon carcinoma cell line [Hct116], and breast carcinoma cell line MCF7. Materials and Methods: The structures of the resulting c...