Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

• Published in: The FASEB journal Vol. 19; no. 9; pp. 1088 - 1095
• Main Authors: Adlam, Victoria J, Harrison, Joanne C, Porteous, Carolyn M, James, Andrew M, Smith, Robin A. J, Murphy, Michael P, Sammut, Ivan A
• Format: Journal Article
• Language: English
• Published: United States 01.07.2005
• Subjects: Animals; Antioxidants - pharmacology; Cytochromes c - secretion; Heart - drug effects; Heart - physiology; Male; Mitochondria - drug effects; Mitochondria - metabolism; Myocardial Reperfusion Injury - pathology; Myocardial Reperfusion Injury - physiopathology; Myocardial Reperfusion Injury - prevention & control; Organophosphorus Compounds - pharmacology; Oxygen Consumption - drug effects; Protective Agents - pharmacology; Rats; Rats, Wistar; Ubiquinone - analogs & derivatives; Ubiquinone - pharmacology

Mitochondrial oxidative damage contributes to a wide range of pathologies, including cardiovascular disorders and neurodegenerative diseases. Therefore, protecting mitochondria from oxidative damage should be an effective therapeutic strategy. However, conventional antioxidants have limited efficacy...