Efficacy of liquid‐based genetic diagnosis of endometrial cancer

• Published in: Cancer science Vol. 109; no. 12; pp. 4025 - 4032
• Main Authors: Matsuura, Motoki, Yamaguchi, Kiyoshi, Tamate, Masato, Satohisa, Seiro, Teramoto, Mizue, Iwasaki, Masahiro, Sugita, Shintaro, Hasegawa, Tadashi, Koubo, Rika, Takane, Kiyoko, Ikenoue, Tsuneo, Furukawa, Yoichi, Saito, Tsuyoshi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2018; John Wiley and Sons Inc
• Subjects: Adenocarcinoma; amplicon sequencing; beta Catenin - genetics; Cervix; Class I Phosphatidylinositol 3-Kinases - genetics; Curettage; Cytodiagnosis - methods; Cytology; Diagnosis; DNA, Neoplasm - blood; Endometrial cancer; endometrial cytology; Endometrial Neoplasms - diagnosis; Endometrial Neoplasms - genetics; Endometrium; Female; genetic diagnosis; Genetic screening; Genetic Variation; Humans; liquid‐based cytology; Malignancy; Mutation; Original; Ovarian cancer; p53 Protein; Proto-Oncogene Proteins p21(ras) - genetics; PTEN Phosphohydrolase - genetics; PTEN protein; Sensitivity and Specificity; Sequence Analysis, DNA - methods; Tumor Suppressor Protein p53 - genetics; Tumors; Ultrasound; Japan; endometrial cancer; liquid-based cytology; endometrial cytology; amplicon sequencing; genetic diagnosis

Although liquid‐based cytology (LBC) has increased the sensitivity of cytological diagnosis of endometrial cancer (EC) compared with conventional smear cytology, the sensitivity of LBC for the detection of EC is between 70% and 96% and remains unsatisfactory. In the present study, we compared the ef...