Tracking bacterial pathogens with genetically-encoded reporters

• Published in: FEBS letters Vol. 588; no. 15; pp. 2428 - 2436
• Main Authors: Campbell-Valois, F.-X., Sansonetti, Philippe J.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.08.2014
• Subjects: Adaptation, Physiological; Animals; Bacteria - genetics; Bacteria - metabolism; Bacteria - pathogenicity; Bacterial pathogenesis; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial secretion systems; Environment-sensing by bacteria; environmental factors; fluorescence; fluorescent proteins; Genes, Reporter; Genetic Techniques; Gram-negative bacteria; Host–pathogen interaction; Humans; image analysis; immune response; microbial communities; nutrient availability; pathogens; protein-protein interactions; Protein–protein/RNA/DNA interaction assays; secretion; tissues; Transcription; transcription (genetics); Transcription, Genetic; Environment-sensing by bacteria; Host–pathogen interaction; Bacterial secretion systems; Bacterial pathogenesis; Transcription; Protein–protein/RNA/DNA interaction assays

During the infectious process, bacterial pathogens are subject to changes in environmental conditions such as nutrient availability, immune response challenges, bacterial density and physical contacts with targeted host cells. These conditions occur in the colonized organs, in diverse regions within...