Imaging brain response to reward in addictive disorders

• Published in: Annals of the New York Academy of Sciences Vol. 1216; no. 1; pp. 50 - 61
• Main Authors: Hommer, Daniel W., Bjork, James M., Gilman, Jodi M.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.01.2011; Wiley Subscription Services, Inc
• Subjects: Addiction; Addictions; alcohol; Behavior, Addictive - diagnostic imaging; Behavior, Addictive - etiology; Behavior, Addictive - physiopathology; Brain - diagnostic imaging; Brain - physiopathology; Brain mapping; Dopamine; Dopamine receptors; Functional magnetic resonance imaging; Humans; Hypotheses; imaging; impulsive behavior; Impulsivity; Magnetic Resonance Imaging; Models, Neurological; Motivation; Neuroimaging; NMR; Nuclear magnetic resonance; Positron emission tomography; Receptor density; Reinforcement; Reward; Substance-Related Disorders - etiology; Substance-Related Disorders - psychology

We compare the evidence from human neuroimaging studies for and against two of the major hypotheses of how alterations in the brain's reward system underlie addiction. One of these, the impulsivity hypothesis, proposes that addiction is characterized by excessive sensitivity to reward combined...