Comparison of the Effects of Intravenously Bolus‐administered Endothelin‐1 and Infused Angiotensin II on the Subcutaneous Tumor Blood Flow in Anesthetized Rats

• Published in: Cancer science Vol. 82; no. 8; pp. 958 - 963
• Main Authors: Tanda, Shigeru, Hori, Katsuyoshi, Saito, Sachiko, Shinozaki, Mika, Zhang, Qiu‐Hang, Suzuki, Maroh
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.1991; Japanese Cancer Association; John Wiley & Sons, Inc
• Subjects: Anesthesia; Angiotensin; Angiotensin II; Angiotensin II - administration & dosage; Angiotensin II - pharmacology; Animals; Arterial blood pressure; Arterioles; Ascites; Biological and medical sciences; Blood flow; Blood pressure; Blood Pressure - drug effects; Endothelins; Endothelins - administration & dosage; Endothelins - pharmacology; Hepatoma; Hydrogen clearance method; Hypertension; Intravenous administration; Male; Medical sciences; Microcirculation; Microcirculation - drug effects; Neoplasm Transplantation; Neoplasms, Experimental - blood supply; Rat ascites hepatoma; Rats; Regional Blood Flow - drug effects; Tumor vessel; Tumors; Vasoconstriction - drug effects; Pathophysiology; Rat; Rodentia; Endothelin 1; Biological activity; Blood flow; Vertebrata; Chemotherapy; Mammalia; Cell line; Treatment; Liver cell carcinoma; Arterial pressure; Tumor; Angiotensin II

To evaluate the effects of endothelin‐1 (ET‐1) on tumor blood flow, the authors measured the mean arterial blood pressure (MABP) of enflurane‐anesthetized male Donryu rats and the tissue blood flow of subcutaneously implanted tumor (Yoshida rat ascites hepatoma LY‐80) by using a hydrogen clearance m...