Noncoding RNA transcription at enhancers and genome folding in cancer

• Published in: Cancer science Vol. 110; no. 8; pp. 2328 - 2336
• Main Authors: Isoda, Takeshi, Morio, Tomohiro, Takagi, Masatoshi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2019; John Wiley and Sons Inc
• Subjects: Animals; cancer; Cell differentiation; Cell lineage; Cohesin; Demethylation; Deoxyribonucleic acid; DNA; DNA methylation; DNA-directed RNA polymerase; Enhancer Elements, Genetic - genetics; Enhancers; Gene expression; Gene loci; Genome - genetics; genome folding; Genomes; Humans; Immunoglobulins; Kinases; Leukemia; Localization; Lymphocytes; Lymphoma; Neoplasms - genetics; noncoding RNA; Phenotypes; Phosphorylation; Promoter Regions, Genetic - genetics; Proteins; Review; RNA polymerase; RNA, Untranslated - genetics; Severe combined immunodeficiency; ThymoD; transcription; Transcription factors; Transcription, Genetic - genetics; cancer; noncoding RNA; ThymoD; transcription; genome folding

Changes of nuclear localization of lineage‐specific genes from a transcriptionally inert to permissive environment are a crucial step in establishing the identity of a cell. Noncoding RNA transcription‐mediated genome folding and activation of target gene expression have been found in a variety of c...