Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer

• Published in: Cancer science Vol. 111; no. 2; pp. 304 - 311
• Main Authors: Loo, Tze Mun, Miyata, Kenichi, Tanaka, Yoko, Takahashi, Akiko
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2020; John Wiley and Sons Inc
• Subjects: AMP; Cancer; Cancer therapies; Cell cycle; Cell growth; Cell proliferation; Cellular Senescence; cGAS‐STING; Chromatin; Cyclic GMP; Cytokines; Cytoplasm - genetics; Deoxyribonucleic acid; DNA; DNA Damage; Epigenetics; Fibroblasts; Gene expression; Gene Expression Regulation, Neoplastic; Genotype & phenotype; Growth factors; Humans; Immune response; Immunity, Innate; Innate immunity; Interferon; Kinases; Membrane Proteins - metabolism; Mitochondrial DNA; Molecular modelling; Neoplasms - genetics; Neoplasms - metabolism; Nucleotidyltransferases - metabolism; Obesity; Phenotype; Phenotypes; Physiology; Proteins; Review; SASP; Senescence; Signal Transduction; Therapeutic applications; Tumor Microenvironment; Tumor suppression; Tumorigenesis; Tumors; Wound healing; cellular senescence; tumorigenesis; cGAS-STING; SASP; DNA damage

Cellular senescence is historically regarded as a tumor suppression mechanism to prevent damaged cells from aberrant proliferation in benign and premalignant tumors. However, recent findings have suggested that senescent cells contribute to tumorigenesis and age‐associated pathologies through the se...