Immune infiltration in renal cell carcinoma

• Published in: Cancer science Vol. 110; no. 5; pp. 1564 - 1572
• Main Authors: Zhang, Shichao, Zhang, Erdong, Long, Jinhua, Hu, Zuquan, Peng, Jian, Liu, Lina, Tang, Fuzhou, Li, Long, Ouyang, Yan, Zeng, Zhu
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2019; John Wiley and Sons Inc
• Subjects: Algorithms; Antigens, CD - metabolism; Biomarkers; Carcinoma, Papillary - immunology; Carcinoma, Papillary - metabolism; Carcinoma, Papillary - pathology; Carcinoma, Renal Cell - immunology; Carcinoma, Renal Cell - metabolism; Carcinoma, Renal Cell - pathology; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Clear cell-type renal cell carcinoma; Clinical outcomes; Colorectal cancer; CTLA-4 Antigen - metabolism; CTLA-4 protein; Female; Gene expression; genomic alterations; Humans; Immune checkpoint; Immunomodulation; Immunoregulation; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Kidney cancer; Kidney Neoplasms - immunology; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Liver cancer; Lymphocytes; Lymphocytes T; Lymphocytes, Tumor-Infiltrating - metabolism; Macrophages; Macrophages - metabolism; Male; Medical prognosis; Metastases; Methods; Mutation; Neoplasm Staging; Original; overall survival; Patients; Prognosis; Programmed Cell Death 1 Ligand 2 Protein - metabolism; renal cell carcinoma; Studies; Survival Analysis; T-Lymphocytes, Regulatory - metabolism; Therapeutic applications; Tumors; tumor‐infiltrating immune cells; overall survival; tumor-infiltrating immune cells; renal cell carcinoma; genomic alterations; prognosis

Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma (RCC). Tumor‐infiltrating immune cells (TIICs) regulate cancer progression and are appealing therapeutic targets. The purpose of this study was to determine the composition of TIICs in RCC and further r...