Active K‐RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro

• Published in: Cancer science Vol. 109; no. 12; pp. 4045 - 4055
• Main Authors: Hirata, Eishu, Ichikawa, Takehiko, Horike, Shin‐ichi, Kiyokawa, Etsuko
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2018; John Wiley and Sons Inc
• Subjects: Animals; beta Catenin - metabolism; Cancer; Carcinoma; Catenin; CCNB1; Cell adhesion & migration; cell cluster; Cell cycle; Cell migration; Cell Movement; Cell Proliferation; Cyclin B1; Cyclin B1 - metabolism; cyst; Cysts; Dogs; Drug screening; Epithelial cells; Epithelial Cells - cytology; Epithelial Cells - metabolism; Glands; Kinases; live imaging; Localization; Lymph nodes; Lymphatic system; Madin Darby Canine Kidney Cells; Medical prognosis; Metastases; Metastasis; Microscopy; Models, Biological; Mutation; Neutrophils; Original; Plasma; Proto-Oncogene Proteins p21(ras) - metabolism; quantification; Signal Transduction; Single-Cell Analysis; Tumors; Japan; live imaging; cyst; CCNB1; quantification; cell cluster

At the invasive front of adenocarcinomas, single cells and multicellular structures exist; the latter include glands and cell clusters, such as tumor buddings and poorly differentiated clusters. Recent reports suggest the importance of collective cell migration in metastasis; however, it is technica...