Whole genome sequencing analysis for cancer genomics and precision medicine

• Published in: Cancer science Vol. 109; no. 3; pp. 513 - 522
• Main Authors: Nakagawa, Hidewaki, Fujita, Masashi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2018; John Wiley and Sons Inc
• Subjects: Antigens; Bias; Biomarkers; Cancer; cancer genome; Computer applications; Consortia; Deoxyribonucleic acid; DNA; DNA methylation; Epigenomics; Genetic Predisposition to Disease; Genomes; Genomics; High-Throughput Nucleotide Sequencing; Humans; Immunology; Immunotherapy; Introns; Lung cancer; Melanoma; Mutation; mutational signature; Neoplasms - genetics; non‐coding mutation; Phenotypes; Precision medicine; Precision Medicine - methods; Proteins; Regulatory sequences; Review; Ribonucleic acid; RNA; Sequence Analysis, RNA; structural variant; Thematic Section: Cancer Genomics; Tumors; whole genome sequencing; Whole Genome Sequencing - methods; whole genome sequencing; cancer genome; structural variant; mutational signature; non-coding mutation

Explosive advances in next‐generation sequencer (NGS) and computational analyses have enabled exploration of somatic protein‐altered mutations in most cancer types, with coding mutation data intensively accumulated. However, there is limited information on somatic mutations in non‐coding regions, in...