Role of the adaptive immune system in diabetic kidney disease

Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro‐inflammatory milieu and subsequently renal fibrosi...

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Published inJournal of diabetes investigation Vol. 13; no. 2; pp. 213 - 226
Main Authors Kong, Lingyun, Andrikopoulos, Sofianos, MacIsaac, Richard J, Mackay, Laura K, Nikolic‐Paterson, David J, Torkamani, Niloufar, Zafari, Neda, Marin, Evelyn C S, Ekinci, Elif I
Format Journal Article
LanguageEnglish
Published Japan John Wiley & Sons, Inc 01.02.2022
John Wiley and Sons Inc
Wiley
Subjects
Adaptive immune system
Albuminuria
Blood pressure
Cell activation
Cell growth
Creatinine
Cytokines
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Diabetic kidney disease
Diabetic Nephropathies - complications
Diabetic nephropathy
Fibrosis
Genotype & phenotype
Hemoglobin
Humans
Hyperglycemia
Immune System
Inflammation
Innate immunity
Interferon
Kidney
Kidney diseases
Lymphocytes
Lymphocytes T
Metabolism
Peptides
Public health
Renal cortex
Renal function
Review
Signal transduction
Adaptive immune system
Inflammation
Diabetic kidney disease
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Abstract Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro‐inflammatory milieu and subsequently renal fibrosis, and a progressive loss of renal function. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the number of T cells in the circulation and in the kidney cortex, that in turn triggers secretion of inflammatory mediators such as interferon‐γ and tumor necrosis factor‐α, and activation of cells in innate immune response. In human studies, the number of T cells residing in the interstitial region of the kidney correlates with the degree of albuminuria in people with type 2 diabetes. Here, we review the role of the adaptive immune system, and associated cytokines, in the development of DKD. Furthermore, the potential therapeutic benefits of targeting the adaptive immune system as a means of preventing the progression of DKD are discussed. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Here, we review the role of the T and B cells of the adaptive immune system, and associated cytokines, in the development of diabetic kidney disease.
AbstractList Abstract Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro‐inflammatory milieu and subsequently renal fibrosis, and a progressive loss of renal function. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the number of T cells in the circulation and in the kidney cortex, that in turn triggers secretion of inflammatory mediators such as interferon‐γ and tumor necrosis factor‐α, and activation of cells in innate immune response. In human studies, the number of T cells residing in the interstitial region of the kidney correlates with the degree of albuminuria in people with type 2 diabetes. Here, we review the role of the adaptive immune system, and associated cytokines, in the development of DKD. Furthermore, the potential therapeutic benefits of targeting the adaptive immune system as a means of preventing the progression of DKD are discussed.
Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end-stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro-inflammatory milieu and subsequently renal fibrosis, and a progressive loss of renal function. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the number of T cells in the circulation and in the kidney cortex, that in turn triggers secretion of inflammatory mediators such as interferon-γ and tumor necrosis factor-α, and activation of cells in innate immune response. In human studies, the number of T cells residing in the interstitial region of the kidney correlates with the degree of albuminuria in people with type 2 diabetes. Here, we review the role of the adaptive immune system, and associated cytokines, in the development of DKD. Furthermore, the potential therapeutic benefits of targeting the adaptive immune system as a means of preventing the progression of DKD are discussed.Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end-stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro-inflammatory milieu and subsequently renal fibrosis, and a progressive loss of renal function. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the number of T cells in the circulation and in the kidney cortex, that in turn triggers secretion of inflammatory mediators such as interferon-γ and tumor necrosis factor-α, and activation of cells in innate immune response. In human studies, the number of T cells residing in the interstitial region of the kidney correlates with the degree of albuminuria in people with type 2 diabetes. Here, we review the role of the adaptive immune system, and associated cytokines, in the development of DKD. Furthermore, the potential therapeutic benefits of targeting the adaptive immune system as a means of preventing the progression of DKD are discussed.
Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro‐inflammatory milieu and subsequently renal fibrosis, and a progressive loss of renal function. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the number of T cells in the circulation and in the kidney cortex, that in turn triggers secretion of inflammatory mediators such as interferon‐γ and tumor necrosis factor‐α, and activation of cells in innate immune response. In human studies, the number of T cells residing in the interstitial region of the kidney correlates with the degree of albuminuria in people with type 2 diabetes. Here, we review the role of the adaptive immune system, and associated cytokines, in the development of DKD. Furthermore, the potential therapeutic benefits of targeting the adaptive immune system as a means of preventing the progression of DKD are discussed.
Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro‐inflammatory milieu and subsequently renal fibrosis, and a progressive loss of renal function. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the number of T cells in the circulation and in the kidney cortex, that in turn triggers secretion of inflammatory mediators such as interferon‐γ and tumor necrosis factor‐α, and activation of cells in innate immune response. In human studies, the number of T cells residing in the interstitial region of the kidney correlates with the degree of albuminuria in people with type 2 diabetes. Here, we review the role of the adaptive immune system, and associated cytokines, in the development of DKD. Furthermore, the potential therapeutic benefits of targeting the adaptive immune system as a means of preventing the progression of DKD are discussed. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Here, we review the role of the T and B cells of the adaptive immune system, and associated cytokines, in the development of diabetic kidney disease.
Author MacIsaac, Richard J
Marin, Evelyn C S
Mackay, Laura K
Kong, Lingyun
Andrikopoulos, Sofianos
Nikolic‐Paterson, David J
Ekinci, Elif I
Torkamani, Niloufar
Zafari, Neda
AuthorAffiliation 1 Department of Medicine Austin Health, University of Melbourne Melbourne Victoria Australia
4 Department of Nephrology Monash Medical Center and Monash University Center for Inflammatory Diseases Melbourne Victoria Australia
5 Endocrine Center of Excellence Austin Health Melbourne Victoria Australia
3 Department of Microbiology and Immunology Peter Doherty Institute for Infection and Immunity The University of Melbourne Melbourne Victoria Australia
6 College of Sport and Exercise Science Victoria University Melbourne Victoria Australia
2 Department of Endocrinology & Diabetes St Vincent's Hospital Melbourne Melbourne Victoria Australia
AuthorAffiliation_xml – name: 2 Department of Endocrinology & Diabetes St Vincent's Hospital Melbourne Melbourne Victoria Australia
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– name: 3 Department of Microbiology and Immunology Peter Doherty Institute for Infection and Immunity The University of Melbourne Melbourne Victoria Australia
– name: 4 Department of Nephrology Monash Medical Center and Monash University Center for Inflammatory Diseases Melbourne Victoria Australia
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  surname: Kong
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  organization: Austin Health, University of Melbourne
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  orcidid: 0000-0003-2372-395X
  surname: Ekinci
  fullname: Ekinci, Elif I
  email: elif.ekinci@unimelb.edu.au
  organization: Austin Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34845863$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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Issue 2
Keywords Adaptive immune system
Inflammation
Diabetic kidney disease
Language English
License Attribution-NonCommercial-NoDerivs
2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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Snippet Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is recognized as...
Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end-stage kidney disease. Inflammation is recognized as...
Abstract Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is...
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SubjectTerms Adaptive immune system
Albuminuria
Blood pressure
Cell activation
Cell growth
Creatinine
Cytokines
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Diabetic kidney disease
Diabetic Nephropathies - complications
Diabetic nephropathy
Fibrosis
Genotype & phenotype
Hemoglobin
Humans
Hyperglycemia
Immune System
Inflammation
Innate immunity
Interferon
Kidney
Kidney diseases
Lymphocytes
Lymphocytes T
Metabolism
Peptides
Public health
Renal cortex
Renal function
Review
Signal transduction
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Title Role of the adaptive immune system in diabetic kidney disease
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjdi.13725
https://www.ncbi.nlm.nih.gov/pubmed/34845863
https://www.proquest.com/docview/2628888939
https://www.proquest.com/docview/2604830945
https://pubmed.ncbi.nlm.nih.gov/PMC8847140
https://doaj.org/article/6acad139277844aaa238884180b0cf8c
Volume 13
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