Diagnostic and prognostic role of urinary collagens in primary human bladder cancer

• Published in: Cancer science Vol. 108; no. 11; pp. 2221 - 2228
• Main Authors: Miyake, Makito, Morizawa, Yosuke, Hori, Shunta, Tatsumi, Yoshihiro, Onishi, Sayuri, Owari, Takuya, Iida, Kota, Onishi, Kenta, Gotoh, Daisuke, Nakai, Yasushi, Anai, Satoshi, Chihara, Yoshitomo, Torimoto, Kazumasa, Aoki, Katsuya, Tanaka, Nobumichi, Shimada, Keiji, Konishi, Noboru, Fujimoto, Kiyohide
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.11.2017; John Wiley and Sons Inc
• Subjects: Aged; Antigens, Neoplasm - urine; Biomarkers; Biomarkers, Tumor - urine; Bladder cancer; Cellular biology; Collagen; Collagen - urine; Collagen Type IV - urine; Cytokeratin; Cytology; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Neoplastic; Glycoproteins - urine; Humans; Invasiveness; Keratin-19 - urine; Male; Matrix protein; Middle Aged; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - urine; Nuclear Proteins - urine; Original; Patients; Prognosis; Proteins; recurrence; Risk factors; Surgery; Surveillance; Tumors; urinary bladder neoplasm; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - urine; Urine; Urothelial cancer; United States > US; recurrence; urinary bladder neoplasm; urine; Collagen; enzyme-linked immunosorbent assay

Collagen type 4 alpha 1 (COL4A1) and collagen type 13 alpha 1 (COL13A1) produced by urothelial cancer cells support the vital oncogenic property of tumor invasion. We investigated the diagnostic and prognostic capability of COL4A1 and COL13A1 in voided urine and compared the observed values with tho...