Using recursive partitioning approach to select tumor‐associated antigens in immunodiagnosis of gastric adenocarcinoma

• Published in: Cancer science Vol. 110; no. 6; pp. 1829 - 1841
• Main Authors: Qin, Jiejie, Wang, Shuaibing, Shi, Jianxiang, Ma, Yan, Wang, Keyan, Ye, Hua, Zhang, Xiaojun, Wang, Peng, Wang, Xiao, Song, Chunhua, Dai, Liping, Wang, Kaijuan, Jiang, Binghua, Zhang, Jianying
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2019; John Wiley and Sons Inc
• Subjects: Adenocarcinoma; Adenocarcinoma - diagnosis; Adenocarcinoma - immunology; Adult; Aged; Aged, 80 and over; Antigen (tumor-associated); Antigens; Antigens, Neoplasm - blood; Antigens, Neoplasm - immunology; Autoantibodies; Autoantibodies - blood; Autoantibodies - immunology; autoantibody; biomarker; Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - immunology; Cancer therapies; Carbohydrates; Case-Control Studies; Enzyme immunoassay; Esophagus; Female; Gastrectomy; gastric adenocarcinoma; Gastric cancer; Humans; Immunodiagnosis; Immunoglobulins; Immunologic Tests - methods; Lymphatic system; Male; Medical prognosis; Metastases; Metastasis; Middle Aged; Mortality; Multivariate Analysis; Original; p53 Protein; Patients; Prediction models; PTEN protein; recursive partitioning approach; ROC Curve; Statistical analysis; Stomach Neoplasms - diagnosis; Stomach Neoplasms - immunology; Studies; Surgery; tumor‐associated antigen; Young Adult; China; recursive partitioning approach; autoantibody; gastric adenocarcinoma; tumor-associated antigen; biomarker

The present study aimed to select anti‐tumor‐associated antigen (TAA) autoantibodies as biomarkers in the immunodiagnosis of gastric adenocarcinoma (GAC) by the recursive partitioning approach (RPA) and further construct and evaluate a predictive model. A case‐control study was designed including 40...