Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 - Shintoku, Ryosuke; Takigawa, Yuta; Yamada, Keiichi; Kubota, Chisato; Yoshimoto, Yuhei; Takeuchi, Toshiyuki; Koshiishi, Ichiro; Torii, Seiji (Cancer science, 2017)
Keywords: Apoptosis; Arachidonate 15-Lipoxygenase - genetics; Cancer; Carbolines - administration & dosage; Cell death; Cell Death - drug effects; Cell Line, Tumor; Cell membranes; Fatty acids; Ferroptosis; Fibrosarcoma - drug therapy; Fibrosarcoma - genetics; Fibrosarcoma - pathology; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; glutathione peroxidase; Humans; Immunofluorescence; Immunoglobulins; iron; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Lipoxygenase; Membranes; Original; Oxidation; Pancreatic Neoplasms; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Piperazines - administration & dosage; Ras; Reactive oxygen species; RNA, Small Interfering; siRNA; United States--US; Japan; iron; Cell death; Ras; reactive oxygen species; glutathione peroxidase