Low‐grade prostate cancer diverges early from high grade and metastatic disease

• Published in: Cancer science Vol. 105; no. 8; pp. 1079 - 1085
• Main Authors: VanderWeele, David J., Brown, Christopher D., Taxy, Jerome B., Gillard, Marc, Hatcher, David M., Tom, Westin R., Stadler, Walter M., White, Kevin P.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2014; Blackwell Publishing Ltd
• Subjects: Aged; Biomarkers; Carcinoma/genetics; Cell cycle; Deoxyribonucleic acid; DNA; DNA Mutational Analysis; exomes; Genes; genetic heterogeneity; Genomes; Humans; Immunohistochemistry; Laser Capture Microdissection; Lymphatic system; Male; Medical research; Metastases; Metastasis; Middle Aged; Mortality; multiple primary neoplasms; Mutation; Neoplasm Grading; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Neoplasm Metastasis - genetics; Neoplasm Metastasis - pathology; Original; p53 Protein; Principal components analysis; Prostate cancer; prostatic neoplasms; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Signal transduction; Tumors; United States > US; Carcinoma/genetics; exomes; multiple primary neoplasms; prostatic neoplasms; genetic heterogeneity
• ISSN: 1347-9032; 1349-7006; 1349-7006
• DOI: 10.1111/cas.12460

Understanding the developmental relationship between indolent and aggressive tumors is central to understanding disease progression and making treatment decisions. For example, most men diagnosed with prostate cancer have clinically indolent disease and die from other causes. Overtreatment of prosta...