VX‐765 ameliorates renal injury and fibrosis in diabetes by regulating caspase‐1‐mediated pyroptosis and inflammation - Wen, Si; Deng, Fei; Li, Lulu; Xu, Li; Li, Xin; Fan, Qiuling (Journal of diabetes investigation, 2022)
Keywords: Animals; Antibodies; Antigens; Apoptosis; Balloon treatment; Caspase; Caspase 1 - metabolism; Caspase‐1; CD45 antigen; Cell culture; Cell Culture Techniques; Cell death; Cell membranes; Collagen (type I); Creatinine; Cytotoxicity; Dehydrogenases; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - pathology; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - pathology; Diabetic nephropathy; Dipeptides - pharmacology; Enzyme-linked immunosorbent assay; Epilepsy; Fibronectin; Fibrosis; Flow cytometry; Glucose; Glucose - pharmacology; GSDMD; Humans; Immunoprecipitation; Immunoreactivity; Inflammation; Kidney - pathology; Kidney Tubules - drug effects; Kidney Tubules - pathology; Laboratory animals; Male; Mice; Microscopy; Nephropathy; Original; para-Aminobenzoates - pharmacology; Pyroptosis; Pyroptosis - drug effects; Renal cortex; Renal function; Urine; VX‐765; United States--US; China; GSDMD; Diabetic nephropathy; Inflammation; Pyroptosis; VX-765; Caspase-1