Effect of crocetin from Gardenia Jasminoides Ellis on sleep: A pilot study

Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial...

Full description

Saved in:
Bibliographic Details
Published inPhytomedicine (Stuttgart) Vol. 17; no. 11; pp. 840 - 843
Main Authors Kuratsune, H., Umigai, N., Takeno, R., Kajimoto, Y., Nakano, T.
Format Journal Article
LanguageEnglish
Published Germany Elsevier GmbH 01.09.2010
Urban & Fischer Verlag
Subjects
Actigraph
Adult
Care and treatment
Carotenoids
Carotenoids - pharmacology
Carotenoids - therapeutic use
Chemical properties
Crocetin
Cross-Over Studies
Double-Blind Method
Fruit
Gardenia
Gardenia - chemistry
Gardenia jasminoides Ellis
Health aspects
Humans
Male
Middle Aged
Phytotherapy
Pilot Projects
Pilot study
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Sleep
Sleep - drug effects
Sleep apnea syndromes
Sleep Initiation and Maintenance Disorders - drug therapy
St Mary's Hospital Sleep Questionnaire
Visual analogue scale
Japan
Pilot study
Gardenia jasminoides Ellis
Actigraph
Sleep
St Mary's Hospital Sleep Questionnaire
Visual analogue scale
Crocetin
Online AccessGet full text

Cover

Abstract Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep complaint. It included two intervention periods of 2 weeks each, separated by a 2-week washout period. We measured objective sleep quality using an actigraph, and assessed the subjective symptoms using St Mary's Hospital Sleep Questionnaire. Actigraph data showed that after administration of crocetin, the number of wakening episodes was reduced compared to that of the placebo ( p = 0.025). Subjective data from St Mary's Hospital Sleep Questionnaire showed that crocetin tended to improve the quality of sleep compared to sleep before its intake. Additionally, no side effects from crocetin intake were observed. The results suggest that crocetin may contribute to improving the quality of sleep.
AbstractList Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep complaint. It included two intervention periods of 2 weeks each, separated by a 2-week washout period. We measured objective sleep quality using an actigraph, and assessed the subjective symptoms using St Mary's Hospital Sleep Questionnaire. Actigraph data showed that after administration of crocetin, the number of wakening episodes was reduced compared to that of the placebo ( p = 0.025). Subjective data from St Mary's Hospital Sleep Questionnaire showed that crocetin tended to improve the quality of sleep compared to sleep before its intake. Additionally, no side effects from crocetin intake were observed. The results suggest that crocetin may contribute to improving the quality of sleep.
Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep complaint. It included two intervention periods of 2 weeks each, separated by a 2-week washout period. We measured objective sleep quality using an actigraph, and assessed the subjective symptoms using St Mary's Hospital Sleep Questionnaire. Actigraph data showed that after administration of crocetin, the number of wakening episodes was reduced compared to that of the placebo (p=0.025). Subjective data from St Mary's Hospital Sleep Questionnaire showed that crocetin tended to improve the quality of sleep compared to sleep before its intake. Additionally, no side effects from crocetin intake were observed. The results suggest that crocetin may contribute to improving the quality of sleep.
Audience Academic
Author Takeno, R.
Kuratsune, H.
Nakano, T.
Umigai, N.
Kajimoto, Y.
Author_xml – sequence: 1
  givenname: H.
  surname: Kuratsune
  fullname: Kuratsune, H.
  organization: Department of Health Science, Faculty of Health Science for Welfare, Kansai University of Welfare Sciences, 3-11-1 Asahigaoka, Kashiwara, Osaka, 582-0026, Japan
– sequence: 2
  givenname: N.
  surname: Umigai
  fullname: Umigai, N.
  email: nao_umigai@rike-vita.co.jp
  organization: Riken Vitamin Co. Ltd, 3F Kousaikaikan Bldg., 5-1, Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
– sequence: 3
  givenname: R.
  surname: Takeno
  fullname: Takeno, R.
  organization: Soiken Inc., 1-4-2 Shinsenri-higashimachi, Toyonaka, Osaka, 560-0082, Japan
– sequence: 4
  givenname: Y.
  surname: Kajimoto
  fullname: Kajimoto, Y.
  organization: Soiken Inc., 1-4-2 Shinsenri-higashimachi, Toyonaka, Osaka, 560-0082, Japan
– sequence: 5
  givenname: T.
  surname: Nakano
  fullname: Nakano, T.
  organization: Riken Vitamin Co. Ltd, 3F Kousaikaikan Bldg., 5-1, Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20537515$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtr3DAUhUVJaSZp_0Epgi6ysqOHX-qiMIRpmhDopoXuhCxdpRpsyZU8gfn3kXGyKAxFC8HRd-5F51ygMx88IPSRkpIS2lzvy-nPcQRTMpIlwkvC6jdoQxvaFUTUv8_QhoiqKlpK-Tm6SGlPCK1ES96hc0Zq3ta03qD7nbWgZxws1jFomJ3HNoYR36powDuF71UanQ_OQMK7YXAJB4_TADB9wVs8uSHMOM0Hc3yP3lo1JPjwcl-iX992P2--Fw8_bu9utg-FrjmbC2stsYJZplRjdNf0lnOrbFWpvhWV6FhvlWibXhDbMMFMVjRRyuhWaC5ExS_R1Tp3iuHvAdIsR5c0DIPyEA5JtnXGGtHxTH5eyUc1gHTehjkqvdByyyoiaMfqZV5xgnoED1ENOXPrsvwPX57g8zEwOn3SUK2GnHBKEaycohtVPEpK5NKl3Mu1S7l0KQmXucts-_Tyz0O_vL2aXsvLwNcVgJz2k4Mok3bgNRgXc6fSBPf_Dc-TNbFt
CitedBy_id crossref_primary_10_6114_jkood_2016_29_2_056
crossref_primary_10_1016_j_fct_2019_05_017
crossref_primary_10_3390_nu12040936
crossref_primary_10_1089_jmf_2017_4064
crossref_primary_10_3389_fphar_2021_745683
crossref_primary_10_1002_jssc_202300469
crossref_primary_10_1186_s12864_023_09666_x
crossref_primary_10_1016_j_jep_2022_114984
crossref_primary_10_3390_plants11030281
crossref_primary_10_1155_2015_761238
crossref_primary_10_1007_s40495_019_00177_6
crossref_primary_10_1016_j_ctim_2018_09_003
crossref_primary_10_1625_jcam_14_9
crossref_primary_10_1186_s40814_020_00602_4
crossref_primary_10_1371_journal_pone_0256802
crossref_primary_10_1002_ptr_5130
crossref_primary_10_1016_j_phymed_2010_10_019
crossref_primary_10_1039_C9FO01166H
crossref_primary_10_1016_j_foodres_2024_113981
crossref_primary_10_1080_14620316_2023_2179548
crossref_primary_10_1016_j_jfda_2016_11_005
crossref_primary_10_3136_nskkk_65_393
crossref_primary_10_29328_journal_afns_1001054
crossref_primary_10_1038_s41598_018_36576_w
crossref_primary_10_3390_nu13051473
crossref_primary_10_1016_j_jbiotec_2023_07_009
crossref_primary_10_1039_C5FO00205B
crossref_primary_10_1080_10286020_2012_723203
crossref_primary_10_1080_10408398_2013_879467
crossref_primary_10_1080_10408398_2020_1738999
crossref_primary_10_3390_ijerph191811658
crossref_primary_10_1155_2023_9633764
crossref_primary_10_1155_2013_686351
crossref_primary_10_3389_fnut_2022_886244
crossref_primary_10_12677_HJFNS_2016_53009
crossref_primary_10_1097_NT_0000000000000449
crossref_primary_10_3390_nu14091712
crossref_primary_10_1016_j_indcrop_2023_117969
crossref_primary_10_6116_kjh_2013_28_2_17
crossref_primary_10_1007_s10068_015_0039_6
crossref_primary_10_3390_v16010094
crossref_primary_10_1016_j_crfs_2023_100462
crossref_primary_10_3390_nu11061382
crossref_primary_10_1016_S1875_5364_23_60405_4
crossref_primary_10_1021_acs_jafc_5b03194
crossref_primary_10_15204_jkobgy2014_27_1_001
Cites_doi 10.1093/sleep/4.1.93
10.1016/S1389-9457(00)00098-8
10.1142/S0192415X03001338
10.1016/S0165-1781(00)00232-8
10.1142/S0219635208001903
10.1016/j.phymed.2006.11.028
10.1164/ajrccm/138.2.337
10.1016/j.phymed.2008.06.005
10.1021/jf0509355
10.1093/sleep/26.3.342
10.1067/mhn.2002.122699
10.1016/0165-1781(89)90047-4
10.1038/40775
10.1016/j.smrv.2007.07.007
10.1016/j.nutres.2009.02.003
10.1093/sleep/23.1.1a
10.1093/sleep/11.5.448
10.2188/jea.10.79
10.1161/HYPERTENSIONAHA.108.123711
10.1016/j.pbb.2005.06.007
10.1093/sleep/18.4.288
10.1007/s11010-005-9088-0
10.1016/j.bcp.2005.07.034
ContentType Journal Article
Copyright 2010 Elsevier GmbH
Copyright 2010 Elsevier GmbH. All rights reserved.
COPYRIGHT 2010 Urban & Fischer Verlag
Copyright_xml – notice: 2010 Elsevier GmbH
– notice: Copyright 2010 Elsevier GmbH. All rights reserved.
– notice: COPYRIGHT 2010 Urban & Fischer Verlag
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1016/j.phymed.2010.03.025
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Pharmacy, Therapeutics, & Pharmacology
EISSN 1618-095X
EndPage 843
ExternalDocumentID A240918254
10_1016_j_phymed_2010_03_025
20537515
S0944711310001200
Genre Randomized Controlled Trial
Journal Article
Comparative Study
GeographicLocations Japan
GeographicLocations_xml – name: Japan
GroupedDBID ---
--K
--M
.~1
0R~
123
1B1
1~.
1~5
29O
3V.
4.4
457
4G.
53G
5VS
7-5
71M
7RV
7X2
7X7
88E
88I
8AF
8FE
8FH
8FI
8FJ
8P~
8R4
8R5
9JM
AABNK
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AAKPP
AALRI
AAOAW
AAQFI
AAQXK
AATCM
AAWTL
AAXUO
AAYOK
ABBQC
ABFNM
ABFRF
ABGSF
ABJNI
ABLVK
ABMAC
ABMZM
ABUDA
ABUWG
ABXDB
ABYKQ
ABZDS
ACDAQ
ACGFO
ACGFS
ACGOD
ACRLP
ADBBV
ADEZE
ADMUD
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AFKRA
AFKWA
AFRAH
AFTJW
AFXIZ
AGHFR
AGRDE
AGUBO
AGYEJ
AHHHB
AHMBA
AIEXJ
AIKHN
AITUG
AIXEN
AJBFU
AJOXV
AJRQY
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
ATCPS
AVWKF
AXJTR
AZFZN
AZQEC
BENPR
BES
BHPHI
BKEYQ
BKOJK
BLXMC
BNPGV
BPHCQ
BVXVI
CAG
CCPQU
COF
CS3
DOVZS
DU5
DWQXO
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
EX3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
FYUFA
G-Q
GBLVA
GNUQQ
HCIFZ
HMCUK
HVGLF
HX~
HZ~
IAG
IAO
IEA
IHA
IHE
IHR
INH
INR
IOF
ISR
J1W
KOM
LCYCR
M0K
M1P
M2P
M2Q
M41
MO0
N9A
NAPCQ
O-L
O9-
OAUVE
OGGZJ
OZT
P-8
P-9
P2P
PC.
PCD
PQQKQ
PROAC
PSQYO
PV9
Q2X
Q38
R2-
RIG
ROL
RPZ
RWL
RXW
RZL
S0X
SCC
SDF
SDG
SEL
SES
SEW
SPCBC
SSH
SSP
SSU
SSZ
T5I
T5K
TAE
UKHRP
UNMZH
WOW
~G-
~KM
AAHBH
AAXKI
AFJKZ
AKRWK
ALIPV
CGR
CUY
CVF
ECM
EIF
ITC
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c532t-fff0f92f2aa6dc86bf33faf44ab794982bfa976b90f6292d982c0aadc79c39943
IEDL.DBID .~1
ISSN 0944-7113
IngestDate Fri Oct 25 00:21:05 EDT 2024
Wed Jul 24 18:23:00 EDT 2024
Wed Nov 13 05:22:20 EST 2024
Tue Nov 12 23:37:28 EST 2024
Thu Sep 26 15:50:56 EDT 2024
Sat Sep 28 08:32:54 EDT 2024
Fri Feb 23 02:20:49 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords Pilot study
Gardenia jasminoides Ellis
Actigraph
Sleep
St Mary's Hospital Sleep Questionnaire
Visual analogue scale
Crocetin
Language English
License Copyright 2010 Elsevier GmbH. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c532t-fff0f92f2aa6dc86bf33faf44ab794982bfa976b90f6292d982c0aadc79c39943
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
PMID 20537515
PQID 753996983
PQPubID 23479
PageCount 4
ParticipantIDs proquest_miscellaneous_753996983
gale_infotracmisc_A240918254
gale_infotracgeneralonefile_A240918254
gale_infotracacademiconefile_A240918254
crossref_primary_10_1016_j_phymed_2010_03_025
pubmed_primary_20537515
elsevier_sciencedirect_doi_10_1016_j_phymed_2010_03_025
PublicationCentury 2000
PublicationDate 2010-09-01
PublicationDateYYYYMMDD 2010-09-01
PublicationDate_xml – month: 09
  year: 2010
  text: 2010-09-01
  day: 01
PublicationDecade 2010
PublicationPlace Germany
PublicationPlace_xml – name: Germany
PublicationTitle Phytomedicine (Stuttgart)
PublicationTitleAlternate Phytomedicine
PublicationYear 2010
Publisher Elsevier GmbH
Urban & Fischer Verlag
Publisher_xml – name: Elsevier GmbH
– name: Urban & Fischer Verlag
References Doi, Minowa, Uchiyama, Okawa, Kim, Shibui, Kamei (bib9) 2000; 97
Ahmad, Ansari, Ahmad, Saleem, Yousuf, Hoda, Islam (bib1) 2005; 81
Barnett, Cooper (bib5) 2008; 7
Masuda, Ueda, Hara, Uozato (bib18) 2008; 25
Sadeh, Hauri, Kripke, Lavie (bib24) 1995; 18
Walsh, Benca, Bonnet, Buysse, Hauri, Kiley, Monan, Morin, Ricca, Rogus, Roth, Simon (bib25) 1999; 59
Magesh, Singh, Selvendiran, Ekambaram, Sakthisekaran (bib17) 2006; 287
Kushida, Chang, Gadkary, Guilleminault, Carrillo, Dement (bib15) 2001; 2
Findley, Unverzagt, Suratt (bib11) 1988; 138
Nagaki, Hayasaka, Abe, Zhang, Hayasaka, Terasawa (bib21) 2003; 31
Buysse, Reynolds, Monk, Berman, Kupfer (bib6) 1989; 28
Ziegler, Ploch, Miettinen-Baumann, Collet (bib29) 2002; 7
Xi, Qian, Du, Fu (bib26) 2007; 14
Ellis, Johns, Lancaster, Raptopoulos, Angelopoulos, Priest (bib10) 1981; 4
Floras (bib12) 2009; 53
Dawson, Reid (bib7) 1997; 388
Ancoli-Israel, Cole, Alessi, Chambers, Moorcroft, Pollack (bib2) 2003; 26
Pitsikas, Boultadakis, Georgiadou, Tarantilis, Sakellaridis (bib22) 2008; 15
Meerlo, Sgoifo, Suchwcki (bib19) 2008; 12
Asai, Nakano, Takahashi, Nagao (bib3) 2005; 53
Kim, Uchiyama, Okawa, Liu, Ogihara (bib14) 2000; 23
Attele, Xie, Yuan (bib4) 2000; 5
Doi, Minowa, Okawa, Uchiyama (bib8) 2000; 10
Powell, Schechtman, Riley, Guilleminault (bib23) 2002; 126
Zheng, Qian, Tang, Sheng (bib28) 2005; 70
Yamadera, Inagawa, Chiba, Bannai, Takahashi, Nakayama (bib27) 2006; 4
Kajita, Umigai, Nakano, Amano, Takeno, Kajimoto (bib13) 2007; 28
Leigh, Bird, Hindmarch, Constable, Wright (bib16) 1988; 11
Mizuma, Tanaka, Nozaki, Mizuno, Tahara, Ataka, Sugino, Shirai, Kajimoto, Kuratsune, Kajimoto, Watanabe (bib20) 2009; 29
Ahmad (10.1016/j.phymed.2010.03.025_bib1) 2005; 81
Attele (10.1016/j.phymed.2010.03.025_bib4) 2000; 5
Magesh (10.1016/j.phymed.2010.03.025_bib17) 2006; 287
Nagaki (10.1016/j.phymed.2010.03.025_bib21) 2003; 31
Leigh (10.1016/j.phymed.2010.03.025_bib16) 1988; 11
Kushida (10.1016/j.phymed.2010.03.025_bib15) 2001; 2
Masuda (10.1016/j.phymed.2010.03.025_bib18) 2008; 25
Powell (10.1016/j.phymed.2010.03.025_bib23) 2002; 126
Meerlo (10.1016/j.phymed.2010.03.025_bib19) 2008; 12
Walsh (10.1016/j.phymed.2010.03.025_bib25) 1999; 59
Doi (10.1016/j.phymed.2010.03.025_bib8) 2000; 10
Zheng (10.1016/j.phymed.2010.03.025_bib28) 2005; 70
Buysse (10.1016/j.phymed.2010.03.025_bib6) 1989; 28
Floras (10.1016/j.phymed.2010.03.025_bib12) 2009; 53
Xi (10.1016/j.phymed.2010.03.025_bib26) 2007; 14
Findley (10.1016/j.phymed.2010.03.025_bib11) 1988; 138
Ellis (10.1016/j.phymed.2010.03.025_bib10) 1981; 4
Ancoli-Israel (10.1016/j.phymed.2010.03.025_bib2) 2003; 26
Doi (10.1016/j.phymed.2010.03.025_bib9) 2000; 97
Pitsikas (10.1016/j.phymed.2010.03.025_bib22) 2008; 15
Yamadera (10.1016/j.phymed.2010.03.025_bib27) 2006; 4
Asai (10.1016/j.phymed.2010.03.025_bib3) 2005; 53
Mizuma (10.1016/j.phymed.2010.03.025_bib20) 2009; 29
Kim (10.1016/j.phymed.2010.03.025_bib14) 2000; 23
Barnett (10.1016/j.phymed.2010.03.025_bib5) 2008; 7
Dawson (10.1016/j.phymed.2010.03.025_bib7) 1997; 388
Ziegler (10.1016/j.phymed.2010.03.025_bib29) 2002; 7
Sadeh (10.1016/j.phymed.2010.03.025_bib24) 1995; 18
Kajita (10.1016/j.phymed.2010.03.025_bib13) 2007; 28
References_xml – volume: 25
  start-page: 119
  year: 2008
  end-page: 122
  ident: bib18
  article-title: Effect of accommodative function on lack of sleep
  publication-title: Atarashii Ganka
  contributor:
    fullname: Uozato
– volume: 53
  start-page: 64
  year: 2009
  end-page: 69
  ident: bib12
  article-title: Hypertension, sleep apnea and atherosclerosis
  publication-title: Hypertension
  contributor:
    fullname: Floras
– volume: 59
  start-page: 3029
  year: 1999
  end-page: 3038
  ident: bib25
  article-title: Insomnia: assessment and management in primary care
  publication-title: Am. Fam. Physician
  contributor:
    fullname: Simon
– volume: 26
  start-page: 342
  year: 2003
  end-page: 392
  ident: bib2
  article-title: The role of actigraphy in the study of sleep and circadian rhythms
  publication-title: Sleep
  contributor:
    fullname: Pollack
– volume: 18
  start-page: 288
  year: 1995
  end-page: 302
  ident: bib24
  article-title: The role of actigraphy in the evaluation of sleep disorders
  publication-title: Sleep
  contributor:
    fullname: Lavie
– volume: 7
  start-page: 480
  year: 2002
  end-page: 486
  ident: bib29
  article-title: Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia—a randomized, double-blind, comparative clinical study
  publication-title: Eur. J. Med. Res.
  contributor:
    fullname: Collet
– volume: 23
  start-page: 41
  year: 2000
  end-page: 47
  ident: bib14
  article-title: An epidemiological study of insomnia among the Japanese general population
  publication-title: Sleep
  contributor:
    fullname: Ogihara
– volume: 4
  start-page: 93
  year: 1981
  end-page: 97
  ident: bib10
  article-title: The St. Mary's Hospital Sleep Questionnaire: a study of reliability
  publication-title: Sleep
  contributor:
    fullname: Priest
– volume: 4
  start-page: 75
  year: 2006
  end-page: 77
  ident: bib27
  article-title: Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes
  publication-title: Sleep Biol. Rhythm
  contributor:
    fullname: Nakayama
– volume: 53
  start-page: 7302
  year: 2005
  end-page: 7306
  ident: bib3
  article-title: Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice
  publication-title: J. Agric. Food Chem.
  contributor:
    fullname: Nagao
– volume: 31
  start-page: 729
  year: 2003
  end-page: 738
  ident: bib21
  article-title: Effects of oral administration of
  publication-title: Am. J. Chin. Med.
  contributor:
    fullname: Terasawa
– volume: 11
  start-page: 448
  year: 1988
  end-page: 453
  ident: bib16
  article-title: Factor analysis of the St. Mary's Hospital Sleep Questionnaire
  publication-title: Sleep
  contributor:
    fullname: Wright
– volume: 287
  start-page: 127
  year: 2006
  end-page: 135
  ident: bib17
  article-title: Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies
  publication-title: Mol. Cell Biochem.
  contributor:
    fullname: Sakthisekaran
– volume: 81
  start-page: 805
  year: 2005
  end-page: 813
  ident: bib1
  article-title: Neuroprotection by crocetin in a hemi-parkinsonian rat model
  publication-title: Pharmacol. Biochem. Behav.
  contributor:
    fullname: Islam
– volume: 5
  start-page: 249
  year: 2000
  end-page: 259
  ident: bib4
  article-title: Treatment of insomnia: an alternative approach
  publication-title: Altern. Med. Rev.
  contributor:
    fullname: Yuan
– volume: 10
  start-page: 79
  year: 2000
  end-page: 86
  ident: bib8
  article-title: Prevalence of sleep disturbance and hypnotic medication use in relation to sociodemographic factors in the general Japanese adult population
  publication-title: J. Epidemiol.
  contributor:
    fullname: Uchiyama
– volume: 29
  start-page: 145
  year: 2009
  end-page: 150
  ident: bib20
  article-title: Daily oral administration of crocetin attenuates physical fatigue in human
  publication-title: Nutr. Res.
  contributor:
    fullname: Watanabe
– volume: 14
  start-page: 633
  year: 2007
  end-page: 636
  ident: bib26
  article-title: Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats
  publication-title: Phytomedicine
  contributor:
    fullname: Fu
– volume: 2
  start-page: 389
  year: 2001
  end-page: 396
  ident: bib15
  article-title: Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients
  publication-title: Sleep Med.
  contributor:
    fullname: Dement
– volume: 15
  start-page: 1135
  year: 2008
  end-page: 1139
  ident: bib22
  article-title: Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety
  publication-title: Phytomedicine
  contributor:
    fullname: Sakellaridis
– volume: 388
  start-page: 235
  year: 1997
  ident: bib7
  article-title: Fatigue, alcohol and performance impairment
  publication-title: Nature
  contributor:
    fullname: Reid
– volume: 138
  start-page: 337
  year: 1988
  end-page: 340
  ident: bib11
  article-title: Automobile accidents involving patients with sleep apnea
  publication-title: Am. Rev. Respir. Dis.
  contributor:
    fullname: Suratt
– volume: 28
  start-page: 193
  year: 1989
  end-page: 213
  ident: bib6
  article-title: The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
  publication-title: Psychiatry Res.
  contributor:
    fullname: Kupfer
– volume: 97
  start-page: 165
  year: 2000
  end-page: 172
  ident: bib9
  article-title: Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects
  publication-title: Psychiatry Res.
  contributor:
    fullname: Kamei
– volume: 126
  start-page: 217
  year: 2002
  end-page: 227
  ident: bib23
  article-title: Sleepy driving: accidents and injury
  publication-title: Otolaryngol. Head Neck Surg.
  contributor:
    fullname: Guilleminault
– volume: 12
  start-page: 197
  year: 2008
  end-page: 210
  ident: bib19
  article-title: Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity
  publication-title: Sleep Med. Rev.
  contributor:
    fullname: Suchwcki
– volume: 70
  start-page: 1192
  year: 2005
  end-page: 1199
  ident: bib28
  article-title: Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits
  publication-title: Biochem. Pharmacol.
  contributor:
    fullname: Sheng
– volume: 7
  start-page: 405
  year: 2008
  end-page: 420
  ident: bib5
  article-title: The effects of a poor nights sleep on mood, cognitive, autonomic and electrophysiological measures
  publication-title: J. Integr. Neurosci.
  contributor:
    fullname: Cooper
– volume: 28
  start-page: 77
  year: 2007
  end-page: 84
  ident: bib13
  article-title: Effect on asthenopia of high-crocetin-content
  publication-title: Jpn. J. Vis. Sci.
  contributor:
    fullname: Kajimoto
– volume: 4
  start-page: 93
  year: 1981
  ident: 10.1016/j.phymed.2010.03.025_bib10
  article-title: The St. Mary's Hospital Sleep Questionnaire: a study of reliability
  publication-title: Sleep
  doi: 10.1093/sleep/4.1.93
  contributor:
    fullname: Ellis
– volume: 2
  start-page: 389
  year: 2001
  ident: 10.1016/j.phymed.2010.03.025_bib15
  article-title: Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients
  publication-title: Sleep Med.
  doi: 10.1016/S1389-9457(00)00098-8
  contributor:
    fullname: Kushida
– volume: 31
  start-page: 729
  year: 2003
  ident: 10.1016/j.phymed.2010.03.025_bib21
  article-title: Effects of oral administration of Gardeniae fructus extract and intravenous injection of crocetin on lipopolysaccharide- and prostaglandin E2-induced elevation of aqueous flare in pigmented rabbits
  publication-title: Am. J. Chin. Med.
  doi: 10.1142/S0192415X03001338
  contributor:
    fullname: Nagaki
– volume: 97
  start-page: 165
  year: 2000
  ident: 10.1016/j.phymed.2010.03.025_bib9
  article-title: Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects
  publication-title: Psychiatry Res.
  doi: 10.1016/S0165-1781(00)00232-8
  contributor:
    fullname: Doi
– volume: 7
  start-page: 405
  year: 2008
  ident: 10.1016/j.phymed.2010.03.025_bib5
  article-title: The effects of a poor nights sleep on mood, cognitive, autonomic and electrophysiological measures
  publication-title: J. Integr. Neurosci.
  doi: 10.1142/S0219635208001903
  contributor:
    fullname: Barnett
– volume: 14
  start-page: 633
  year: 2007
  ident: 10.1016/j.phymed.2010.03.025_bib26
  article-title: Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2006.11.028
  contributor:
    fullname: Xi
– volume: 138
  start-page: 337
  year: 1988
  ident: 10.1016/j.phymed.2010.03.025_bib11
  article-title: Automobile accidents involving patients with sleep apnea
  publication-title: Am. Rev. Respir. Dis.
  doi: 10.1164/ajrccm/138.2.337
  contributor:
    fullname: Findley
– volume: 15
  start-page: 1135
  year: 2008
  ident: 10.1016/j.phymed.2010.03.025_bib22
  article-title: Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2008.06.005
  contributor:
    fullname: Pitsikas
– volume: 53
  start-page: 7302
  year: 2005
  ident: 10.1016/j.phymed.2010.03.025_bib3
  article-title: Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf0509355
  contributor:
    fullname: Asai
– volume: 26
  start-page: 342
  year: 2003
  ident: 10.1016/j.phymed.2010.03.025_bib2
  article-title: The role of actigraphy in the study of sleep and circadian rhythms
  publication-title: Sleep
  doi: 10.1093/sleep/26.3.342
  contributor:
    fullname: Ancoli-Israel
– volume: 126
  start-page: 217
  year: 2002
  ident: 10.1016/j.phymed.2010.03.025_bib23
  article-title: Sleepy driving: accidents and injury
  publication-title: Otolaryngol. Head Neck Surg.
  doi: 10.1067/mhn.2002.122699
  contributor:
    fullname: Powell
– volume: 59
  start-page: 3029
  year: 1999
  ident: 10.1016/j.phymed.2010.03.025_bib25
  article-title: Insomnia: assessment and management in primary care
  publication-title: Am. Fam. Physician
  contributor:
    fullname: Walsh
– volume: 28
  start-page: 193
  year: 1989
  ident: 10.1016/j.phymed.2010.03.025_bib6
  article-title: The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
  publication-title: Psychiatry Res.
  doi: 10.1016/0165-1781(89)90047-4
  contributor:
    fullname: Buysse
– volume: 28
  start-page: 77
  year: 2007
  ident: 10.1016/j.phymed.2010.03.025_bib13
  article-title: Effect on asthenopia of high-crocetin-content Gardenia Jasminoides ellis extraction
  publication-title: Jpn. J. Vis. Sci.
  contributor:
    fullname: Kajita
– volume: 388
  start-page: 235
  year: 1997
  ident: 10.1016/j.phymed.2010.03.025_bib7
  article-title: Fatigue, alcohol and performance impairment
  publication-title: Nature
  doi: 10.1038/40775
  contributor:
    fullname: Dawson
– volume: 12
  start-page: 197
  year: 2008
  ident: 10.1016/j.phymed.2010.03.025_bib19
  article-title: Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity
  publication-title: Sleep Med. Rev.
  doi: 10.1016/j.smrv.2007.07.007
  contributor:
    fullname: Meerlo
– volume: 25
  start-page: 119
  year: 2008
  ident: 10.1016/j.phymed.2010.03.025_bib18
  article-title: Effect of accommodative function on lack of sleep
  publication-title: Atarashii Ganka
  contributor:
    fullname: Masuda
– volume: 29
  start-page: 145
  year: 2009
  ident: 10.1016/j.phymed.2010.03.025_bib20
  article-title: Daily oral administration of crocetin attenuates physical fatigue in human
  publication-title: Nutr. Res.
  doi: 10.1016/j.nutres.2009.02.003
  contributor:
    fullname: Mizuma
– volume: 23
  start-page: 41
  year: 2000
  ident: 10.1016/j.phymed.2010.03.025_bib14
  article-title: An epidemiological study of insomnia among the Japanese general population
  publication-title: Sleep
  doi: 10.1093/sleep/23.1.1a
  contributor:
    fullname: Kim
– volume: 11
  start-page: 448
  year: 1988
  ident: 10.1016/j.phymed.2010.03.025_bib16
  article-title: Factor analysis of the St. Mary's Hospital Sleep Questionnaire
  publication-title: Sleep
  doi: 10.1093/sleep/11.5.448
  contributor:
    fullname: Leigh
– volume: 10
  start-page: 79
  year: 2000
  ident: 10.1016/j.phymed.2010.03.025_bib8
  article-title: Prevalence of sleep disturbance and hypnotic medication use in relation to sociodemographic factors in the general Japanese adult population
  publication-title: J. Epidemiol.
  doi: 10.2188/jea.10.79
  contributor:
    fullname: Doi
– volume: 7
  start-page: 480
  year: 2002
  ident: 10.1016/j.phymed.2010.03.025_bib29
  article-title: Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia—a randomized, double-blind, comparative clinical study
  publication-title: Eur. J. Med. Res.
  contributor:
    fullname: Ziegler
– volume: 5
  start-page: 249
  year: 2000
  ident: 10.1016/j.phymed.2010.03.025_bib4
  article-title: Treatment of insomnia: an alternative approach
  publication-title: Altern. Med. Rev.
  contributor:
    fullname: Attele
– volume: 53
  start-page: 64
  year: 2009
  ident: 10.1016/j.phymed.2010.03.025_bib12
  article-title: Hypertension, sleep apnea and atherosclerosis
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.108.123711
  contributor:
    fullname: Floras
– volume: 81
  start-page: 805
  year: 2005
  ident: 10.1016/j.phymed.2010.03.025_bib1
  article-title: Neuroprotection by crocetin in a hemi-parkinsonian rat model
  publication-title: Pharmacol. Biochem. Behav.
  doi: 10.1016/j.pbb.2005.06.007
  contributor:
    fullname: Ahmad
– volume: 18
  start-page: 288
  year: 1995
  ident: 10.1016/j.phymed.2010.03.025_bib24
  article-title: The role of actigraphy in the evaluation of sleep disorders
  publication-title: Sleep
  doi: 10.1093/sleep/18.4.288
  contributor:
    fullname: Sadeh
– volume: 4
  start-page: 75
  year: 2006
  ident: 10.1016/j.phymed.2010.03.025_bib27
  article-title: Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes
  publication-title: Sleep Biol. Rhythm
  contributor:
    fullname: Yamadera
– volume: 287
  start-page: 127
  year: 2006
  ident: 10.1016/j.phymed.2010.03.025_bib17
  article-title: Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies
  publication-title: Mol. Cell Biochem.
  doi: 10.1007/s11010-005-9088-0
  contributor:
    fullname: Magesh
– volume: 70
  start-page: 1192
  year: 2005
  ident: 10.1016/j.phymed.2010.03.025_bib28
  article-title: Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2005.07.034
  contributor:
    fullname: Zheng
SSID ssj0014970
Score 2.1993704
Snippet Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The...
Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The...
SourceID proquest
gale
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 840
SubjectTerms Actigraph
Adult
Care and treatment
Carotenoids
Carotenoids - pharmacology
Carotenoids - therapeutic use
Chemical properties
Crocetin
Cross-Over Studies
Double-Blind Method
Fruit
Gardenia
Gardenia - chemistry
Gardenia jasminoides Ellis
Health aspects
Humans
Male
Middle Aged
Phytotherapy
Pilot Projects
Pilot study
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Sleep
Sleep - drug effects
Sleep apnea syndromes
Sleep Initiation and Maintenance Disorders - drug therapy
St Mary's Hospital Sleep Questionnaire
Visual analogue scale
Title Effect of crocetin from Gardenia Jasminoides Ellis on sleep: A pilot study
URI https://dx.doi.org/10.1016/j.phymed.2010.03.025
https://www.ncbi.nlm.nih.gov/pubmed/20537515
https://search.proquest.com/docview/753996983
Volume 17
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3BTtwwEB0hKiEuVQu03ZYiH9ByIWwS7ybr3lYIWHYFQhQEN8t27CoVTVYkHLj02zsTJ6BFSJU4RXImUuyxZ8bJe88AuyPKctxmAeeRbig5gcqsDQgS5YTlWSiI73x2nkyvh7Pb0e0KHHZcGIJVtrHfx_QmWrctg3Y0B4s8H_zEjQlG1qj5Qh2hs4nBjukP5_TB3yeYB24AmgPjyDgg644-12C8sCeYc1qAFz8I6cDs19PTy3j9ogptstHxB3jflpFs4t_0I6zYYgPWztof5RvQv_CS1I_77OqZYVXtsz67eBarftyEmZcvZqVjhnJZnReMKCfsRBG_IVdspqo_eVHmma0YITwqVhasurN28YNN2CK_K2vWiNRuwfXx0dXhNGjPVwjMiMd14JwLnYhdrFSSmXGiHedOueFQaVylYhxrp7Ba0SJ0SSziDFtMqFRmUmGwrhnyT7BalIX9AmyUGsOjxKVcY0miE61TjYVbLEgdKDTjHgTdsMqFl9GQHb7st_RukOQGGXKJbuhB2o29XJoOEiP9f57cI1dJWp_1vTKqpRnge5LSlZxgCSMi2hf3oL9k-cvrfL9muL1kiAvQLN1m3ayQdItQa4UtHyqZkuxvIsa8B5_9bHnqfEw6OlhLfn1zR7_BukcyEN5tG1br-wf7HQukWu80K2AH3k1O59Nzus4vb-b_AKyIDxg
link.rule.ids 315,783,787,4509,24128,27936,27937,45597,45691
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3BbtQwEB2VIgEXBAXKQgs-oOXSdJM4m6y5raqWZelWldhKvVm2Y6Ogkqya9NAL385MnLTaqlKlXuOJZHvsmefkzTPAlzFlOW7zgPNItyU5gcqtDYgS5YTleSio3nlxks7Okvn5-HwDDvpaGKJVdrHfx_Q2WndPRt1sjlZFMfqFBxOMrFH7hTpCZz-BpwnhY1zU-_9ueB54AmhvjCPrgMz7-rmW5IVDwaTTMbz4fkg3Zt-fn-4G7DswtE1HR6_gZYcj2dR39TVs2HILni26P-VbMDz1mtTXe2x5W2JV77EhO71Vq75-A3OvX8wqxwwls6YoGdWcsO-KChwKxeaq_luUVZHbmhHFo2ZVyeoLa1ff2JStiouqYa1K7Vs4OzpcHsyC7oKFwIx53ATOudCJ2MVKpbmZpNpx7pRLEqVxm4pJrJ1CuKJF6NJYxDk-MaFSucmEQWCT8HewWValfQ9snBnDo9RlXCMm0anWmUbkFguSBwrNZABBP61y5XU0ZE8w-yO9GyS5QYZcohsGkPVzL9fWg8RQ_8CbX8lVkjZoc6mM6uoMsJ8kdSWniGFERAfjAQzXLH97oe_7DHfWDHEHmrVm1q8KSU1EWyttdVXLjHR_UzHhA9j2q-Vm8DEJ6SCY_PDogX6G57Pl4lge_zj5-RFeeFoDkd92YLO5vLK7iJYa_andDf8BZpgPDg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+crocetin+from+Gardenia+jasminoides+Ellis+on+sleep%3A+a+pilot+study&rft.jtitle=Phytomedicine+%28Stuttgart%29&rft.au=Kuratsune%2C+H&rft.au=Umigai%2C+N&rft.au=Takeno%2C+R&rft.au=Kajimoto%2C+Y&rft.date=2010-09-01&rft.pub=Urban+%26+Fischer+Verlag&rft.issn=0944-7113&rft.eissn=1618-095X&rft.volume=17&rft.issue=11&rft.spage=840&rft_id=info:doi/10.1016%2Fj.phymed.2010.03.025&rft.externalDocID=A240918254
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0944-7113&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0944-7113&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0944-7113&client=summon