Targeting Gas6/TAM in cancer cells and tumor microenvironment

• Published in: Molecular cancer Vol. 17; no. 1; pp. 20 - 10
• Main Authors: Wu, Guiling, Ma, Zhiqiang, Cheng, Yicheng, Hu, Wei, Deng, Chao, Jiang, Shuai, Li, Tian, Chen, Fulin, Yang, Yang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.01.2018; BioMed Central; BMC
• Subjects: Analysis; Animals; Axl Receptor Tyrosine Kinase; Biomarkers, Tumor; c-Mer Tyrosine Kinase - antagonists & inhibitors; c-Mer Tyrosine Kinase - metabolism; Cancer; Cancer cells; Care and treatment; Cell Line, Tumor; Cell Proliferation; Cell Survival - genetics; Fibroblasts; Growth arrest-specific 6; Humans; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Metastasis; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Staging; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Proto-Oncogene Proteins - antagonists & inhibitors; Proto-Oncogene Proteins - metabolism; Receptor Protein-Tyrosine Kinases - antagonists & inhibitors; Receptor Protein-Tyrosine Kinases - metabolism; Review; Tumor Microenvironment - drug effects; Tumor Microenvironment - genetics; Tumour microenvironment; Growth arrest-specific 6; Tumour microenvironment; Cancer cells

Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological proces...