Over 1-year efficacy and safety of left atrial appendage occlusion versus novel oral anticoagulants for stroke prevention in atrial fibrillation: A systematic review and meta-analysis of randomized controlled trials and observational studies

• Published in: Heart rhythm Vol. 13; no. 6; pp. 1203 - 1214
• Main Authors: Li, Xin, Wen, Song-Nan, Li, Song-Nan, Bai, Rong, Liu, Nian, Feng, Li, Ruan, Yan-Fei, Du, Xin, Dong, Jian-Zeng, Ma, Chang-Sheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016
• Subjects: Anticoagulants - pharmacology; Atrial Appendage - surgery; Atrial fibrillation; Atrial Fibrillation - complications; Atrial Fibrillation - therapy; Cardiovascular; Humans; Left atrial appendage occlusion; Meta-analysis; Novel oral anticoagulant; Prosthesis Implantation - methods; Randomized Controlled Trials as Topic; Septal Occluder Device; Stroke - etiology; Stroke - prevention & control; Stroke prevention; Treatment Outcome; Novel oral anticoagulant; Left atrial appendage occlusion; Stroke prevention; Atrial fibrillation; Meta-analysis

A direct comparison of the efficacy and safety profiles of left atrial appendage occlusion (LAAO) devices and novel oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation is warranted but currently unavailable. The aim of this study was to compare the >1-year efficacy and safety...