Leaky gut biomarkers in depression and suicidal behavior
Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeabilit...
Saved in:
| Published in | Acta psychiatrica Scandinavica Vol. 139; no. 2; pp. 185 - 193 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.02.2019
John Wiley and Sons Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0001-690X 1600-0447 1600-0447 |
| DOI | 10.1111/acps.12978 |
Cover
| Abstract | Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation.
We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery-Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments.
The rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = -0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05).
The 'leaky gut hypothesis' may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts. |
|---|---|
| AbstractList | OBJECTIVE: Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation. METHOD: We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery-Asberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments. RESULTS: The rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = -0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05). CONCLUSION: The 'leaky gut hypothesis' may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts. ObjectiveInflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation.MethodWe enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I‐FABP), soluble CD14, and interleukin‐6 (IL‐6) were quantified in plasma. Montgomery–Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments.ResultsThe rSA group displayed higher I‐FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL‐6 correlated positively with I‐FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = −0.25, P < 0.05). In all subjects, I‐FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05).ConclusionThe ‘leaky gut hypothesis’ may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts. Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation.OBJECTIVEInflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation.We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery-Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments.METHODWe enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery-Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments.The rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = -0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05).RESULTSThe rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = -0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05).The 'leaky gut hypothesis' may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts.CONCLUSIONThe 'leaky gut hypothesis' may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts. Objective: Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation. Method: We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery–Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments. Results: The rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = −0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05). Conclusion: The ‘leaky gut hypothesis’ may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts. Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation. We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery-Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments. The rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = -0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05). The 'leaky gut hypothesis' may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts. |
| Author | Ohlsson, L. Ljunggren, L. Brundin, L. Lindqvist, D. Westrin, Å. Lavant, E. Suneson, K. Gustafsson, A. |
| AuthorAffiliation | 1 Department of Biomedical Science Malmo University Malmö Sweden 2 Faculty of Medicine Department of Clinical Sciences Lund, Psychiatry Lund University Lund Sweden 3 Center for Neurodegenerative Science Van Andel Research Institute Grand Rapids MI USA |
| AuthorAffiliation_xml | – name: 1 Department of Biomedical Science Malmo University Malmö Sweden – name: 2 Faculty of Medicine Department of Clinical Sciences Lund, Psychiatry Lund University Lund Sweden – name: 3 Center for Neurodegenerative Science Van Andel Research Institute Grand Rapids MI USA |
| Author_xml | – sequence: 1 givenname: L. surname: Ohlsson fullname: Ohlsson, L. organization: Department of Biomedical Science Malmo University Malmö Sweden – sequence: 2 givenname: A. surname: Gustafsson fullname: Gustafsson, A. organization: Department of Biomedical Science Malmo University Malmö Sweden – sequence: 3 givenname: E. surname: Lavant fullname: Lavant, E. organization: Department of Biomedical Science Malmo University Malmö Sweden – sequence: 4 givenname: K. surname: Suneson fullname: Suneson, K. organization: Faculty of Medicine Department of Clinical Sciences Lund, Psychiatry Lund University Lund Sweden – sequence: 5 givenname: L. surname: Brundin fullname: Brundin, L. organization: Center for Neurodegenerative Science Van Andel Research Institute Grand Rapids MI USA – sequence: 6 givenname: Å. surname: Westrin fullname: Westrin, Å. organization: Faculty of Medicine Department of Clinical Sciences Lund, Psychiatry Lund University Lund Sweden – sequence: 7 givenname: L. surname: Ljunggren fullname: Ljunggren, L. organization: Department of Biomedical Science Malmo University Malmö Sweden – sequence: 8 givenname: D. orcidid: 0000-0002-3472-327X surname: Lindqvist fullname: Lindqvist, D. organization: Faculty of Medicine Department of Clinical Sciences Lund, Psychiatry Lund University Lund Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30347427$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-5337$$DView record from Swedish Publication Index |
| BookMark | eNp1kt1rFDEQwINU7LX64h8gC76IsnXytcm-CKV-woEvKr4N2SR7l3Zvc012K_3vTe9asUXzEkJ-M_NjZo7IwRhHT8hzCie0nLfGbvMJZa3Sj8iCNgA1CKEOyAIAaN208POQHOV8Xp6Sgn5CDjlwoQRTC6KX3lxcV6t5qroQNyZd-JSrMFbOb5PPOcSxMqOr8hxscGaoOr82VyGmp-Rxb4bsn93ex-T7xw_fzj7Xy6-fvpydLmsrOZvqnjHdMt9prWlrO-pFrzjY3jvJDHdOgZQ9yNY01EhrWyrBUjC2U53gjCt-TMw-b_7lt3OH2xSK5TVGE3Ab02QGLJ7eJLvGYcbssVBDsGYq6hmNUEpoSrHXACgYaOzAaHSKN06A6xrjSo03_63xPvw4xZhWuDEzSr4zerenC7rxzvpxSsXinti9nzGscRWvsJG6uLQlwavbBClezj5PuAnZ-mEwo49zRlZmKVnbaFHQlw_Q8zinsTS8UAqUbiTwQr342-iPyt2YCwB7wKaYc_I92jDtOlQEw4AU8GaT8GaTcLdJJeT1g5C7rP-AfwNucMrx |
| CitedBy_id | crossref_primary_10_1007_s12035_020_01961_y crossref_primary_10_3390_jcm13020593 crossref_primary_10_3390_nu13113731 crossref_primary_10_1017_S0033291722000897 crossref_primary_10_2139_ssrn_4185912 crossref_primary_10_1111_ejn_15239 crossref_primary_10_3390_ijms241713329 crossref_primary_10_3390_nu13051728 crossref_primary_10_3390_nu12092575 crossref_primary_10_1016_j_heliyon_2022_e11848 crossref_primary_10_1080_1028415X_2022_2110188 crossref_primary_10_1016_j_jad_2020_03_022 crossref_primary_10_1038_s41598_020_75229_9 crossref_primary_10_1007_s12035_024_04205_5 crossref_primary_10_1016_j_phrs_2023_106799 crossref_primary_10_3390_neuroglia4020009 crossref_primary_10_1016_j_yfrne_2019_100772 crossref_primary_10_1016_j_ajp_2024_104210 crossref_primary_10_1016_j_eclinm_2022_101603 crossref_primary_10_3389_fnins_2019_01361 crossref_primary_10_1016_j_ajp_2023_103861 crossref_primary_10_1016_j_biopsych_2023_10_014 crossref_primary_10_1017_gmb_2021_3 crossref_primary_10_1016_j_pnpbp_2020_110169 crossref_primary_10_3389_fpsyt_2024_1395235 crossref_primary_10_3390_ijms221810051 crossref_primary_10_1016_j_brainres_2025_149575 crossref_primary_10_3390_antiox12030623 crossref_primary_10_3389_fped_2019_00432 crossref_primary_10_1016_j_newideapsych_2022_100933 crossref_primary_10_1016_j_bbr_2023_114459 crossref_primary_10_1038_s43587_022_00203_1 crossref_primary_10_3390_nu12071982 crossref_primary_10_3390_ijms25020814 crossref_primary_10_3390_ijms26020485 crossref_primary_10_3390_medicina59071240 crossref_primary_10_1016_j_jadr_2023_100624 crossref_primary_10_1038_s41380_021_01032_1 crossref_primary_10_1038_s41398_024_03031_6 crossref_primary_10_3390_cells9081909 crossref_primary_10_1007_s11481_021_10022_7 crossref_primary_10_1038_s41598_024_53929_w crossref_primary_10_1016_j_ejpsy_2023_100225 crossref_primary_10_1016_j_jad_2024_10_120 crossref_primary_10_1016_j_jad_2020_01_117 crossref_primary_10_17116_jnevro2021121111129 crossref_primary_10_1002_adfm_202409718 crossref_primary_10_1192_j_eurpsy_2024_1765 crossref_primary_10_2147_JIR_S425780 crossref_primary_10_1016_j_neuropharm_2022_109293 crossref_primary_10_3389_fpsyt_2024_1463929 crossref_primary_10_1016_j_ejphar_2022_175171 crossref_primary_10_3390_laws13040046 crossref_primary_10_1017_S0033291722001970 crossref_primary_10_1038_s41572_019_0121_0 crossref_primary_10_1016_j_mcna_2022_09_001 crossref_primary_10_1016_j_mehy_2023_111190 crossref_primary_10_1039_D4FO02221A crossref_primary_10_3389_fpsyt_2019_00812 crossref_primary_10_26442_00403660_2022_08_201523 crossref_primary_10_1111_all_15800 crossref_primary_10_5937_jomb0_43904 crossref_primary_10_1016_j_psyneuen_2024_107119 crossref_primary_10_1002_jmv_29864 crossref_primary_10_1038_s41598_019_52893_0 crossref_primary_10_1016_j_tem_2022_01_002 crossref_primary_10_1016_j_bbi_2019_02_007 crossref_primary_10_3389_fnbeh_2021_693362 crossref_primary_10_3390_metabo12020152 crossref_primary_10_1016_j_autrev_2020_102504 crossref_primary_10_1016_j_euroneuro_2023_05_009 crossref_primary_10_1016_j_yfrne_2024_101173 crossref_primary_10_3390_nu13010096 crossref_primary_10_1016_j_pnpbp_2020_110076 crossref_primary_10_1080_1028415X_2022_2111745 crossref_primary_10_1016_j_nsa_2024_104088 crossref_primary_10_1016_j_nurpra_2021_09_009 crossref_primary_10_1093_nutrit_nuad171 crossref_primary_10_3390_jcm11175121 crossref_primary_10_1080_13651501_2020_1801754 crossref_primary_10_1016_j_jad_2023_07_119 crossref_primary_10_1016_j_pnpbp_2024_111170 crossref_primary_10_1089_jir_2020_0265 crossref_primary_10_1038_s41598_025_91679_5 crossref_primary_10_30773_pi_2022_0234 crossref_primary_10_1038_s41598_021_01248_9 crossref_primary_10_1016_j_jpsychires_2024_06_037 crossref_primary_10_1016_j_eti_2023_103012 crossref_primary_10_1016_j_jad_2020_10_024 crossref_primary_10_31083_j_jin2203065 crossref_primary_10_1155_2020_7897240 crossref_primary_10_1177_11795735251322450 crossref_primary_10_1016_j_jad_2022_11_058 crossref_primary_10_1039_D2FO01478E crossref_primary_10_1016_j_jad_2021_07_021 crossref_primary_10_1016_j_phrs_2024_107541 crossref_primary_10_1016_j_brainresbull_2024_111001 crossref_primary_10_3390_ijms242417618 crossref_primary_10_1016_j_tips_2023_12_007 crossref_primary_10_1017_neu_2023_21 crossref_primary_10_3389_fpsyt_2021_682868 crossref_primary_10_1016_j_bpsgos_2023_04_007 crossref_primary_10_3390_nu12113422 crossref_primary_10_3389_fnins_2022_1029495 crossref_primary_10_7759_cureus_40293 crossref_primary_10_3389_fpsyt_2020_591962 crossref_primary_10_3390_jpm13061003 crossref_primary_10_1126_sciadv_abo2794 crossref_primary_10_3389_fpsyt_2020_00541 crossref_primary_10_1016_j_bbih_2021_100344 crossref_primary_10_1097_FBP_0000000000000585 crossref_primary_10_3390_cells12091240 crossref_primary_10_1111_nmo_14300 crossref_primary_10_3390_ijms241612634 crossref_primary_10_1016_j_lfs_2024_122815 crossref_primary_10_2147_NDT_S360588 crossref_primary_10_1055_a_2090_3594 crossref_primary_10_3390_ijms241813907 crossref_primary_10_31083_j_fbl2910346 crossref_primary_10_1186_s12876_021_02075_y crossref_primary_10_1038_s41398_022_02023_8 |
| Cites_doi | 10.1016/S0009-9120(03)00096-1 10.1186/2049-9256-2-4 10.1053/j.gastro.2017.05.003 10.1038/nrn3071 10.1097/QAD.0000000000000735 10.1016/j.jpsychires.2006.10.013 10.1093/infdis/jiu238 10.1007/s10620-009-0813-5 10.1192/bjp.134.4.382 10.1016/j.bbi.2010.10.010 10.1007/7854_2012_211 10.1136/gutjnl-2017-314759 10.1038/nrmicro2876 10.1136/annrheumdis-2016-210000 10.1038/nature11450 10.1097/SHK.0000000000000440 10.1016/S0165-0327(12)70004-6 10.1038/tp.2014.113 10.1016/j.biopsych.2009.01.030 10.1179/1476830514Y.0000000158 10.1016/j.eurpsy.2006.01.011 10.1155/2017/4835189 10.1152/physrev.00003.2008 10.1038/mp.2015.112 10.1053/j.gastro.2011.06.063 10.1126/scitranslmed.3006438 10.1186/s13075-014-0418-z 10.1016/S0753-3322(00)89047-2 10.1016/S0140-6736(00)02169-3 10.1111/acps.12458 10.1113/jphysiol.2014.273995 10.2217/ijr.11.62 10.1016/j.biopsych.2017.08.005 10.1177/0004867416686694 10.1016/j.jpsychires.2016.07.019 10.1038/nm1511 10.1128/iai.64.5.1762-1769.1996 10.9758/cpn.2015.13.3.239 10.1016/j.biopsych.2009.09.033 10.1136/gut.2005.065557 10.1007/s11010-013-1911-4 10.33549/physiolres.932916 10.1016/j.psychres.2017.08.076 10.1016/j.nut.2015.09.003 10.1186/s12937-016-0204-7 10.1176/appi.ajp.159.5.789 10.1136/gutjnl-2011-300327 10.1007/s40572-016-0100-5 10.1016/j.pnpbp.2004.11.003 10.1016/j.bbi.2011.05.002 10.1111/apt.12194 10.1111/nyas.13416 10.1371/journal.pone.0009085 10.3389/fncel.2015.00392 10.1038/mp.2016.50 10.1128/CMR.00050-12 10.1097/MCG.0b013e3182a87e3e |
| ContentType | Journal Article |
| Copyright | 2018 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. 2019 John Wiley & Sons A/S, Published by John Wiley & Sons Ltd |
| Copyright_xml | – notice: 2018 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. – notice: 2019 John Wiley & Sons A/S, Published by John Wiley & Sons Ltd |
| CorporateAuthor | Psykiatri, Lund Enheten för klinisk suicidforskning Enheten för Biologisk Psykiatri och Precisionspsykiatri Unit for clinical suicide research Institutionen för kliniska vetenskaper, Lund Psychiatry (Lund) Lunds universitet Lund University Department of Clinical Sciences, Lund Unit for Biological and Precision Psychiatry Faculty of Medicine Section IV Medicinska fakulteten Sektion IV |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Institutionen för kliniska vetenskaper, Lund – name: Unit for clinical suicide research – name: Lunds universitet – name: Department of Clinical Sciences, Lund – name: Enheten för Biologisk Psykiatri och Precisionspsykiatri – name: Sektion IV – name: Lund University – name: Section IV – name: Psychiatry (Lund) – name: Enheten för klinisk suicidforskning – name: Unit for Biological and Precision Psychiatry – name: Psykiatri, Lund |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TK K9. 7X8 5PM ADTPV AOWAS D8T ZZAVC AGCHP D95 |
| DOI | 10.1111/acps.12978 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Freely available online SwePub Articles full text SWEPUB Lunds universitet full text SWEPUB Lunds universitet |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Neurosciences Abstracts MEDLINE - Academic |
| DatabaseTitleList | ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Ohlsson et al |
| EISSN | 1600-0447 |
| EndPage | 193 |
| ExternalDocumentID | oai_portal_research_lu_se_publications_a4774811_f800_4208_b0a8_d736d40db6ad oai_DiVA_org_mau_5337 PMC6587489 30347427 10_1111_acps_12978 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GrantInformation_xml | – fundername: Söderström-Königska Foundation – fundername: Sjöbring Foundation – fundername: Marie Sklodowska Curie Actions grantid: INCA 600398 – fundername: Swedish Research Council grantid: 2015-00387 – fundername: Swedish Society of Medicine grantid: 2015-00387 – fundername: Söderström‐Königska Foundation – fundername: Swedish Research Council grantid: 2015‐00387 – fundername: Swedish Society of Medicine grantid: 2015‐00387 |
| GroupedDBID | --- -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 23M 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAYXX AAZKR ABCQN ABCUV ABDBF ABEML ABIVO ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFS ACGOF ACHQT ACMXC ACPOU ACPRK ACRPL ACSCC ACUHS ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUYR AEYWJ AFBPY AFEBI AFFNX AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGYGG AHBTC AHEFC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG CITATION COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DUUFO EAD EAP EAS EBC EBD EBS EJD EMB EMK EMOBN EPS ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO L7B LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OHT OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 UPT V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WVDHM WXI WXSBR X7M XG1 YF5 ZGI ZXP ZZTAW ~IA ~WT CGR CUY CVF ECM EIF NPM 7TK AAMMB AEFGJ AGXDD AIDQK AIDYY K9. 7X8 5PM ADTPV AOWAS D8T ZZAVC AGCHP D95 |
| ID | FETCH-LOGICAL-c532t-f22892eb88819cb1e4f730cfed52a3dd7055f059a61a5cc9150c10acb7b432373 |
| ISSN | 0001-690X 1600-0447 |
| IngestDate | Tue Sep 09 22:39:01 EDT 2025 Thu Aug 21 06:23:16 EDT 2025 Thu Aug 21 18:34:08 EDT 2025 Fri Sep 05 06:47:18 EDT 2025 Sun Sep 07 10:10:41 EDT 2025 Thu Apr 03 06:58:50 EDT 2025 Tue Jul 01 01:06:46 EDT 2025 Thu Apr 24 23:08:30 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | intestinal permeability zonulin suicide, attempted depressive disorder, major intestinal fatty acid binding protein |
| Language | English |
| License | 2018 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c532t-f22892eb88819cb1e4f730cfed52a3dd7055f059a61a5cc9150c10acb7b432373 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 These authors contributed equally to this work. |
| ORCID | 0000-0002-3472-327X |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC6587489 |
| PMID | 30347427 |
| PQID | 2170786503 |
| PQPubID | 33508 |
| PageCount | 9 |
| ParticipantIDs | swepub_primary_oai_portal_research_lu_se_publications_a4774811_f800_4208_b0a8_d736d40db6ad swepub_primary_oai_DiVA_org_mau_5337 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6587489 proquest_miscellaneous_2129529684 proquest_journals_2170786503 pubmed_primary_30347427 crossref_citationtrail_10_1111_acps_12978 crossref_primary_10_1111_acps_12978 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-02-01 |
| PublicationDateYYYYMMDD | 2019-02-01 |
| PublicationDate_xml | – month: 02 year: 2019 text: 2019-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Aalborg – name: Hoboken |
| PublicationTitle | Acta psychiatrica Scandinavica |
| PublicationTitleAlternate | Acta Psychiatr Scand |
| PublicationYear | 2019 |
| Publisher | Blackwell Publishing Ltd John Wiley and Sons Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: John Wiley and Sons Inc |
| References | e_1_2_8_28_1 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_3_1 e_1_2_8_5_1 e_1_2_8_7_1 e_1_2_8_9_1 e_1_2_8_43_1 Maes M (e_1_2_8_20_1) 2008; 29 e_1_2_8_22_1 e_1_2_8_45_1 e_1_2_8_62_1 e_1_2_8_41_1 e_1_2_8_60_1 e_1_2_8_17_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_59_1 e_1_2_8_15_1 e_1_2_8_57_1 Hoffmanova I (e_1_2_8_32_1) 2015; 64 e_1_2_8_55_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_53_1 e_1_2_8_51_1 e_1_2_8_30_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_46_1 e_1_2_8_27_1 e_1_2_8_48_1 e_1_2_8_2_1 e_1_2_8_4_1 e_1_2_8_6_1 BLOM G (e_1_2_8_36_1) 1958 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_23_1 e_1_2_8_44_1 e_1_2_8_40_1 e_1_2_8_61_1 e_1_2_8_18_1 e_1_2_8_39_1 Carabotti M (e_1_2_8_12_1) 2015; 28 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_58_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_56_1 e_1_2_8_33_1 e_1_2_8_54_1 Abautret‐Daly A (e_1_2_8_38_1) 2017; 08 e_1_2_8_52_1 e_1_2_8_50_1 33164213 - Acta Psychiatr Scand. 2020 Nov;142(5):423 |
| References_xml | – ident: e_1_2_8_23_1 doi: 10.1016/S0009-9120(03)00096-1 – volume-title: Statistical estimates and transformed beta‐variables year: 1958 ident: e_1_2_8_36_1 – ident: e_1_2_8_13_1 doi: 10.1186/2049-9256-2-4 – ident: e_1_2_8_43_1 doi: 10.1053/j.gastro.2017.05.003 – ident: e_1_2_8_18_1 doi: 10.1038/nrn3071 – ident: e_1_2_8_27_1 doi: 10.1097/QAD.0000000000000735 – ident: e_1_2_8_9_1 doi: 10.1016/j.jpsychires.2006.10.013 – ident: e_1_2_8_26_1 doi: 10.1093/infdis/jiu238 – ident: e_1_2_8_61_1 doi: 10.1007/s10620-009-0813-5 – ident: e_1_2_8_34_1 doi: 10.1192/bjp.134.4.382 – ident: e_1_2_8_8_1 doi: 10.1016/j.bbi.2010.10.010 – ident: e_1_2_8_4_1 doi: 10.1007/7854_2012_211 – ident: e_1_2_8_37_1 doi: 10.1136/gutjnl-2017-314759 – ident: e_1_2_8_39_1 doi: 10.1038/nrmicro2876 – ident: e_1_2_8_47_1 doi: 10.1136/annrheumdis-2016-210000 – ident: e_1_2_8_45_1 doi: 10.1038/nature11450 – ident: e_1_2_8_24_1 doi: 10.1097/SHK.0000000000000440 – ident: e_1_2_8_50_1 doi: 10.1016/S0165-0327(12)70004-6 – ident: e_1_2_8_10_1 doi: 10.1038/tp.2014.113 – ident: e_1_2_8_33_1 doi: 10.1016/j.biopsych.2009.01.030 – ident: e_1_2_8_14_1 doi: 10.1179/1476830514Y.0000000158 – ident: e_1_2_8_35_1 doi: 10.1016/j.eurpsy.2006.01.011 – ident: e_1_2_8_48_1 doi: 10.1155/2017/4835189 – ident: e_1_2_8_22_1 doi: 10.1152/physrev.00003.2008 – ident: e_1_2_8_54_1 doi: 10.1038/mp.2015.112 – volume: 08 start-page: 1 year: 2017 ident: e_1_2_8_38_1 article-title: Gut‐brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease publication-title: Acta Neuropsychiatr – volume: 29 start-page: 117 year: 2008 ident: e_1_2_8_20_1 article-title: The gut‐brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression publication-title: Neuro Endocrinol Lett – ident: e_1_2_8_30_1 doi: 10.1053/j.gastro.2011.06.063 – ident: e_1_2_8_49_1 doi: 10.1126/scitranslmed.3006438 – ident: e_1_2_8_52_1 doi: 10.1186/s13075-014-0418-z – ident: e_1_2_8_60_1 doi: 10.1016/S0753-3322(00)89047-2 – ident: e_1_2_8_21_1 doi: 10.1016/S0140-6736(00)02169-3 – ident: e_1_2_8_5_1 doi: 10.1111/acps.12458 – ident: e_1_2_8_59_1 doi: 10.1113/jphysiol.2014.273995 – ident: e_1_2_8_53_1 doi: 10.2217/ijr.11.62 – ident: e_1_2_8_6_1 doi: 10.1016/j.biopsych.2017.08.005 – ident: e_1_2_8_44_1 doi: 10.1177/0004867416686694 – ident: e_1_2_8_41_1 doi: 10.1016/j.jpsychires.2016.07.019 – ident: e_1_2_8_29_1 doi: 10.1038/nm1511 – volume: 28 start-page: 203 year: 2015 ident: e_1_2_8_12_1 article-title: The gut‐brain axis: interactions between enteric microbiota, central and enteric nervous systems publication-title: Ann Gastroenterol – ident: e_1_2_8_28_1 doi: 10.1128/iai.64.5.1762-1769.1996 – ident: e_1_2_8_17_1 doi: 10.9758/cpn.2015.13.3.239 – ident: e_1_2_8_2_1 doi: 10.1016/j.biopsych.2009.09.033 – ident: e_1_2_8_56_1 doi: 10.1136/gut.2005.065557 – ident: e_1_2_8_19_1 doi: 10.1007/s11010-013-1911-4 – volume: 64 start-page: 537 year: 2015 ident: e_1_2_8_32_1 article-title: Serological markers of enterocyte damage and apoptosis in patients with celiac disease, autoimmune diabetes mellitus and diabetes mellitus type 2 publication-title: Physiol Res doi: 10.33549/physiolres.932916 – ident: e_1_2_8_7_1 doi: 10.1016/j.psychres.2017.08.076 – ident: e_1_2_8_42_1 doi: 10.1016/j.nut.2015.09.003 – ident: e_1_2_8_57_1 doi: 10.1186/s12937-016-0204-7 – ident: e_1_2_8_51_1 doi: 10.1176/appi.ajp.159.5.789 – ident: e_1_2_8_31_1 doi: 10.1136/gutjnl-2011-300327 – ident: e_1_2_8_40_1 doi: 10.1007/s40572-016-0100-5 – ident: e_1_2_8_3_1 doi: 10.1016/j.pnpbp.2004.11.003 – ident: e_1_2_8_11_1 doi: 10.1016/j.bbi.2011.05.002 – ident: e_1_2_8_25_1 doi: 10.1111/apt.12194 – ident: e_1_2_8_16_1 doi: 10.1111/nyas.13416 – ident: e_1_2_8_46_1 doi: 10.1371/journal.pone.0009085 – ident: e_1_2_8_15_1 doi: 10.3389/fncel.2015.00392 – ident: e_1_2_8_58_1 doi: 10.1038/mp.2016.50 – ident: e_1_2_8_55_1 doi: 10.1128/CMR.00050-12 – ident: e_1_2_8_62_1 doi: 10.1097/MCG.0b013e3182a87e3e – reference: 33164213 - Acta Psychiatr Scand. 2020 Nov;142(5):423 |
| SSID | ssj0005108 |
| Score | 2.586249 |
| Snippet | Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal... ObjectiveInflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal... OBJECTIVE: Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal... Objective: Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal... |
| SourceID | swepub pubmedcentral proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 185 |
| SubjectTerms | Adult Bacterial Translocation - genetics Biomarkers Biomarkers - blood CD14 antigen Clinical Medicine Cross-Sectional Studies Depressive Disorder, Major - diagnosis Depressive Disorder, Major - metabolism Digestive system Enterocytes Enterocytes - microbiology Fatty acid-binding protein Fatty Acid-Binding Proteins - blood Female Gastrointestinal tract Haptoglobins Humans Hypotheses Inflammation Inflammation - metabolism Interleukin-6 - blood Intestine Intestine, Small - cytology Intestine, Small - metabolism Intestine, Small - physiopathology Klinisk medicin Lipopolysaccharide Receptors - blood Male Medical and Health Sciences Medicin och hälsovetenskap Mental depression Middle Aged Original Permeability Plasma levels Protein Precursors - blood Psychiatry Psykiatri Self destructive behavior Severity of Illness Index Suicidal behavior Suicidal Ideation Suicide Suicide, Attempted - psychology Suicides & suicide attempts |
| Title | Leaky gut biomarkers in depression and suicidal behavior |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30347427 https://www.proquest.com/docview/2170786503 https://www.proquest.com/docview/2129529684 https://pubmed.ncbi.nlm.nih.gov/PMC6587489 https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-5337 |
| Volume | 139 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELZgSIgXxG8CAwWxFzRlahI3Th4r2DRBt0nQoooXy7GdtWKkVZs8wF_P5zg_GlYQ8BJVzjVp7y7n-5zvzoQcZInKWCwDL8Hk4yGlHnipFJEXUSZkJBIqBqYa-ew8Op3S97PhrCOxV9UlRXokf-ysK_kfq2IMdjVVsv9g2faiGMBn2BdHWBjHv7LxWIuv3w8vy-LQVNEbos26T2-1TONNuZALBVs0NfnbGelIFqLjPMNkeNyrUhdIdjSei7n5L1tlCoayY2qvsma49YSxQHJe9IocPpUIqFbsw_Yyg6ls6lE2fllOtMtjHfHIxlbfA9ae2ZnFhtPI1K1T21Ozjbe2e1HtWMFW9PTt7j31ROzbrRN_E-OFXG2OkKzYDYD6jbTPL_jJdDzmk-PZ5Ca5FTBm3-B_7DqLIRTZSbr-0XXnWkPy6q7cz1WuAZDrPNpet9kqQ5ncI3draOGOrJ_cJzd0_oDcPqvJEw9JXLmLC3dxO3dxF7nbuYsLy7uNu7iNuzwi05PjydtTr944w5PDMCi8LACMDnQax8j3ZOprmiGQy0yrYSBCpUwHpQx5tYh8MZQyASiQ_kDIlKU0DEIWPiZ7-TLXT4mb-DoWgAhK0QGVYZgyqWKhgYLlUFMdO-RNoyIu667yZnOTK96gS6NOXqnTIa9b2ZXtpbJTar_RNK-ftQ0HcEYuCzQROuRVexqR0LzeErlelkYmSAyLIKYOeWIN094GiRplNGAOYT2TtQKmy3r_TL6YV93WkaKbDk0OObDG7X3l3eLziC_Xl_ybKDmQE27wZYeYhdK87t8151cl32i-2lqY54JCyzE0kQHCcUN64elAxFyxMILuVRoJ9ezPqnlO7nRP7j7ZK9alfoGUuUhfVs7_E999x9g |
| linkProvider | Wiley-Blackwell |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Leaky+gut+biomarkers+in+depression+and+suicidal+behavior&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.au=Ohlsson%2C+L&rft.au=Gustafsson%2C+A&rft.au=Lavant%2C+E&rft.au=Suneson%2C+K&rft.date=2019-02-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0001-690X&rft.eissn=1600-0447&rft.volume=139&rft.issue=2&rft.spage=185&rft.epage=193&rft_id=info:doi/10.1111%2Facps.12978&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0001-690X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0001-690X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0001-690X&client=summon |