Human mesenchymal stromal cells suppress T-cell proliferation independent of heme oxygenase-1

• Published in: Cytotherapy (Oxford, England) Vol. 17; no. 4; pp. 382 - 391
• Main Authors: Patel, Seema R., Copland, Ian B., Garcia, Marco A., Metz, Richard, Galipeau, Jacques
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.04.2015
• Subjects: Adolescent; Adult; Advanced Basic Science; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Female; Heme - metabolism; heme oxygenase 1; Heme Oxygenase-1 - antagonists & inhibitors; Heme Oxygenase-1 - metabolism; Humans; immune modulation; Immune Tolerance; indoleamine 2,3-dioxygenase; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Inflammation - therapy; inflammatory cytokine priming; Interferon-gamma - immunology; Interferon-gamma - pharmacology; Lymphocyte Activation - immunology; Male; mechanism of T-cell suppression; mesenchymal stromal cells; Mesenchymal Stromal Cells - enzymology; Mesenchymal Stromal Cells - immunology; Metalloporphyrins - pharmacology; Other; Protoporphyrins - pharmacology; T-Lymphocytes - immunology; Transforming Growth Factor beta - metabolism; Tumor Necrosis Factor-alpha - metabolism; Young Adult; immune modulation; indoleamine 2,3-dioxygenase; mechanism of T-cell suppression; inflammatory cytokine priming; heme oxygenase 1; mesenchymal stromal cells

Mesenchymal stromal cells deploy immune suppressive properties amenable for use as cell therapy for inflammatory disorders. It is now recognized that mesenchymal stromal cells necessitate priming with an inflammatory milieu, in particular interferon-γ, to exert augmented immunosuppressive effects. I...