Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease

• Published in: Journal of neuroinflammation Vol. 14; no. 1; pp. 175 - 12
• Main Authors: Gallart-Palau, Xavier, Serra, Aida, Lee, Benjamin Sian Teck, Guo, Xue, Sze, Siu Kwan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.09.2017; BioMed Central; BMC
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amino Acid Sequence; Biomarkers - metabolism; Brain - metabolism; Brain - pathology; Carbamylation; Cerebrovascular Disorders - genetics; Cerebrovascular Disorders - metabolism; Cerebrovascular Disorders - pathology; Citrullination; Complications and side effects; Deimination; Development and progression; Female; Genetic aspects; Health aspects; Humans; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Male; Mixed dementias; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Nervous system diseases; Proteinopathy; Risk factors; Singapore; Carbamylation; Citrullination; Deimination; Proteinopathy; Alzheimer’s disease; Mixed dementias

Brain degenerative protein modifications (DPMs) are associated with the apparition and progression of dementia, and at the same time, Alzheimer's disease with cerebrovascular disease (AD + CVD) is the most prevalent form of dementia in the elder population. Thus, understanding the role(s) of br...