Development of a peptide targeting dopamine transporter to improve ADHD-like deficits

• Published in: Molecular brain Vol. 11; no. 1; p. 66
• Main Authors: Lai, Terence K Y, Su, Ping, Zhang, Hailong, Liu, Fang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.11.2018; BioMed Central; BMC
• Subjects: Amino Acid Sequence; Animals; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - physiopathology; Attention deficit hyperactivity disorder; Behavior, Animal - drug effects; Care and treatment; Dopamine - metabolism; Dopamine Plasma Membrane Transport Proteins - metabolism; Dopamine receptors; Health aspects; Male; Motor Activity - drug effects; Movement - drug effects; Peptides - chemistry; Peptides - pharmacology; Peptides - therapeutic use; Rats

Attention-deficit hyperactivity disorder (ADHD) is a neurocognitive disorder characterized by hyperactivity, inattention, working memory deficits and impulsivity. Its worldwide prevalence is estimated to be 3-5% in children and adolescents. The mainstay treatment for ADHD is stimulant medications (e...