PET in neurotherapeutic discovery and development

• Published in: Neurotherapeutics Vol. 22; no. 1; p. e00498
• Main Authors: Chassé, Melissa, Vasdev, Neil
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025; Elsevier
• Subjects: Animals; Carbon-11; Drug Development - methods; Drug Discovery - methods; Fluorine-18; Humans; Neuroimaging; Positron emission tomography; Positron-Emission Tomography - methods; Radiochemistry; Radiopharmaceuticals; Review; Small molecule drug development; Neuroimaging; Carbon-11; Fluorine-18; Small molecule drug development; Positron emission tomography; Radiochemistry
• ISSN: 1878-7479; 1933-7213; 1878-7479
• DOI: 10.1016/j.neurot.2024.e00498

Positron emission tomography (PET) is a highly sensitive, quantitative imaging technique that can track sub-nanomolar quantities of positron-emitting radionuclides throughout the body. By incorporating such radionuclides into molecules of interest, we can directly assess their pharmacokinetic and ph...