Benefit Profile of Thrombomodulin Alfa Combined with Antithrombin Concentrate in Patients with Sepsis-Induced Disseminated Intravascular Coagulation

• Published in: Clinical and applied thrombosis/hemostasis Vol. 28; p. 10760296221077096
• Main Authors: Murao, Atsushi, Kato, Takayuki, Yamane, Tetsunobu, Honda, Goichi, Eguchi, Yutaka
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.02.2022; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Aged; Aged, 80 and over; Anticoagulants; Anticoagulants - administration & dosage; Anticoagulants - therapeutic use; Antithrombins - administration & dosage; Antithrombins - adverse effects; Antithrombins - therapeutic use; Disseminated Intravascular Coagulation - drug therapy; Disseminated Intravascular Coagulation - etiology; Disseminated Intravascular Coagulation - mortality; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Original Manuscript; Platelet Count; Sepsis - complications; Survival analysis; Thrombomodulin - administration & dosage; Thrombomodulin - therapeutic use; anticoagulants; infections; antithrombins; thrombocytopenia; disseminated intravascular coagulation; thrombomodulin

Thrombomodulin alfa (TM-α, recombinant human soluble thrombomodulin) and antithrombin (AT) concentrate are anticoagulant agents for the treatment of disseminated intravascular coagulation (DIC). A post hoc analysis using data from 1198 patients with infection-induced DIC from the post-marketing surv...