Non-nucleoside hepatitis B virus polymerase inhibitors identified by an in vitro polymerase elongation assay

• Published in: Journal of gastroenterology Vol. 55; no. 4; pp. 441 - 452
• Main Authors: Nakajima, Shogo, Watashi, Koichi, Fukano, Kento, Tsukuda, Senko, Wakae, Kousho, Aizaki, Hideki, Muramatsu, Masamichi, Wakita, Takaji, Toyoda, Tetsuya
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.04.2020; Springer; Springer Nature B.V
• Subjects: Abdominal Surgery; Adefovir dipivoxil; Analysis; Antiretroviral drugs; Biliary Tract; Colorectal Surgery; DNA polymerases; Drug delivery; Drug development; Elongation; Enzymes; Gastroenterology; Genomes; Genomics; Health aspects; Hepatitis; Hepatitis B; Hepatology; High-throughput screening; Lamivudine; Medicine; Medicine & Public Health; Nucleosides; Original Article—Liver; Pancreas; Piceatannol; Replication; RNA-directed DNA polymerase; Surface plasmon resonance; Surgical Oncology; Telbivudine; Therapeutic targets; Polymerase; Non-nucleoside; Reverse transcription; Replication; HBV

Background Hepatitis B virus (HBV) polymerase is the only virus-encoded enzyme essential for producing the HBV genome and is regarded as an attractive drug target. However, the difficulty of synthesizing and purifying recombinant HBV polymerase protein has hampered the development of new drugs targe...